S
Sung-Lin Hu
Researcher at China Medical University (Taiwan)
Publications - 16
Citations - 299
Sung-Lin Hu is an academic researcher from China Medical University (Taiwan). The author has contributed to research in topics: Arthritis & Proinflammatory cytokine. The author has an hindex of 5, co-authored 14 publications receiving 164 citations.
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Journal ArticleDOI
Melatonin attenuates TNF-α and IL-1β expression in synovial fibroblasts and diminishes cartilage degradation: Implications for the treatment of rheumatoid arthritis.
Chien-Chung Huang,Chen-Hsiang Chiou,Shan-Chi Liu,Sung-Lin Hu,Chen-Ming Su,Chun-Hao Tsai,Chih-Hsin Tang +6 more
TL;DR: Melatonin dose‐dependently inhibits tumor necrosis factor‐α and interleukin expression through the PI3K/AKT, ERK, NF‐κB signaling pathways, as well as miR‐3150a‐3p overexpression, and significantly reduced paw swelling, cartilage degradation, and bone erosion in the collagen‐induced arthritis mouse model.
Journal ArticleDOI
Myostatin Promotes Interleukin-1β Expression in Rheumatoid Arthritis Synovial Fibroblasts through Inhibition of miR-21-5p.
Sung-Lin Hu,An Chen Chang,Chien-Chung Huang,Chun-Hao Tsai,Cheng-Chieh Lin,Chih-Hsin Tang,Chih-Hsin Tang +6 more
TL;DR: Evidence indicates that myostatin regulates IL-1β production, a key pro-inflammatory cytokine in RA, and may represent a potential therapeutic target for RA.
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Serum homocysteine level is positively associated with chronic kidney disease in a Taiwan Chinese population.
Min Chun Chao,Sung-Lin Hu,Hua-Shui Hsu,Lance E. Davidson,Chih Hsueh Lin,Chia Ing Li,Chiu-Shong Liu,Tsai-Chung Li,Tsai-Chung Li,Cheng-Chieh Lin,Wen-Yuan Lin +10 more
TL;DR: Elevated serum homocysteine levels appear to be closely associated with CKD and negatively correlated to eGFR, and a dose–response effect is revealed.
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CXCL13/CXCR5 axis facilitates endothelial progenitor cell homing and angiogenesis during rheumatoid arthritis progression.
Chun-Hao Tsai,Chao-Ju Chen,Chi-Li Gong,Shan-Chi Liu,Po-Chun Chen,Chien-Chung Huang,Sung-Lin Hu,Shih-Wei Wang,Shih-Wei Wang,Chih-Hsin Tang +9 more
TL;DR: The chemokine (C-X-C motif) ligand 13 (CXCL13) plays important roles in several cellular functions such as infiltration, migration, and motility.
Journal ArticleDOI
Myostatin induces tumor necrosis factor-α expression in rheumatoid arthritis synovial fibroblasts through the PI3K-Akt signaling pathway
Chen-Ming Su,Sung-Lin Hu,Yi Sun,Jin Zhao,Chengqian Dai,Li-Hong Wang,Guo-Hong Xu,Chih-Hsin Tang,Chih-Hsin Tang +8 more
TL;DR: A positive correlation between myostatin and tumor necrosis factor‐α (TNF‐α), a well‐known proinflammatory cytokine, in RA synovial tissue is found and hisostatin appears to be a promising target in RA therapy.