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Sung-Lin Hu

Researcher at China Medical University (Taiwan)

Publications -  16
Citations -  299

Sung-Lin Hu is an academic researcher from China Medical University (Taiwan). The author has contributed to research in topics: Arthritis & Proinflammatory cytokine. The author has an hindex of 5, co-authored 14 publications receiving 164 citations.

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Melatonin attenuates TNF-α and IL-1β expression in synovial fibroblasts and diminishes cartilage degradation: Implications for the treatment of rheumatoid arthritis.

TL;DR: Melatonin dose‐dependently inhibits tumor necrosis factor‐α and interleukin expression through the PI3K/AKT, ERK, NF‐κB signaling pathways, as well as miR‐3150a‐3p overexpression, and significantly reduced paw swelling, cartilage degradation, and bone erosion in the collagen‐induced arthritis mouse model.
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Myostatin Promotes Interleukin-1β Expression in Rheumatoid Arthritis Synovial Fibroblasts through Inhibition of miR-21-5p.

TL;DR: Evidence indicates that myostatin regulates IL-1β production, a key pro-inflammatory cytokine in RA, and may represent a potential therapeutic target for RA.
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Myostatin induces tumor necrosis factor-α expression in rheumatoid arthritis synovial fibroblasts through the PI3K-Akt signaling pathway

TL;DR: A positive correlation between myostatin and tumor necrosis factor‐α (TNF‐α), a well‐known proinflammatory cytokine, in RA synovial tissue is found and hisostatin appears to be a promising target in RA therapy.