S
Susan L. Mooberry
Researcher at University of Texas Health Science Center at San Antonio
Publications - 183
Citations - 6937
Susan L. Mooberry is an academic researcher from University of Texas Health Science Center at San Antonio. The author has contributed to research in topics: Microtubule & Tubulin. The author has an hindex of 44, co-authored 176 publications receiving 6262 citations. Previous affiliations of Susan L. Mooberry include University of Texas System & Texas Biomedical Research Institute.
Papers
More filters
Journal ArticleDOI
Isolation of dolastatin 10 from the marine cyanobacterium Symploca species VP642 and total stereochemistry and biological evaluation of its analogue symplostatin 1.
TL;DR: The potent antitumor agent dolastatin 10 (1) was originally isolated from the sea hare Dolabella auricularia, and it is reported its isolation from the marine cyanobacterium Symploca sp.
Journal Article
Laulimalide and Isolaulimalide, New Paclitaxel-Like Microtubule-Stabilizing Agents
TL;DR: Laulimalides and isolaulimalide represent a new class of microtubule-stabilizing agents with activities that may provide therapeutic utility and, although less potent than paclitaxel, it was more effective.
Journal ArticleDOI
Microtubule dynamics as a target in oncology.
TL;DR: This review discusses the molecular mechanisms as well as preclinical and clinical results for a variety of microtubule-targeting agents in various stages of development and offers a frank discussion of which micro Tubule- targeting agents are amenable to further development based on their availability, efficacy and toxic profile.
Journal Article
Cryptophycin: A New Antimicrotubule Agent Active against Drug-resistant Cells
TL;DR: Indirect immunofluorescence studies demonstrated that treatment of A-10 vascular smooth muscle cells with cryptophycin results in marked depletion of cellular microtubules and reorganization of vimentin intermediate filaments, similar to the effects of vinblastine.
Journal ArticleDOI
Microtubule Interactions with Chemically Diverse Stabilizing Agents: Thermodynamics of Binding to the Paclitaxel Site Predicts Cytotoxicity
Rubén M. Buey,Isabel Barasoain,Evelyn M. Jackson,Arndt Meyer,Paraskevi Giannakakou,Ian Paterson,Susan L. Mooberry,José Manuel Andreu,J. Fernando Díaz +8 more
TL;DR: The inhibition of cell proliferation correlates better with the binding enthalpy change than with thebinding constants, suggesting that large, favorable enthalpic contribution to the binding is desired to design paclitaxel site drugs with higher cytotoxicity.