Showing papers by "Susan L. Morris-Natschke published in 1999"
TL;DR: A good correlation was observed between EC(50) (TEER) and EC10x (mannitol) [concentration that caused 10-fold increase in mannitol transport over the control (untreated) value], confirming that a decrease in TEER is associated with enhanced permeability of the hydrophilic compounds across Caco-2 cell monolayers.
19 citations
TL;DR: In this article, 2.2-Acetyl-4,8-dihydrobenzo and 2.4-acetyl-acetoxyethyl derivatives, together with 10 related mono-and disubstituted derivatives, were synthesized and evaluated in vitro by NC against eight cancer types.
Abstract: 2-Acetyl-4,8-dihydrobenzo[1,2-b:4,5-b']dithiophene-4,8-dione (9) and 2-acetyl-4,8-dihydrobenzo-[1,2-b:5,4-b']dithiophene-4,8-dione (19), together with 10 related mono- and disubstituted derivatives, were synthesized and evaluated in vitro by NC against eight cancer types. All compounds showed significant activity against melanoma, HL-60 leukemia, NCI-H23 non-small-cell lung cancer, OVCAR-3 ovarian cancer, and MDA-MB-435 and MDA-N breast cancer cell lines. Compound 11, 2-(1'-acetoxyethyl)-4,8-dihydrobenzo[1,2-b:4,5-b']dithiophene-4,8-dione, showed the highest overall potency (mean GI 50 = 40 nM).