Susana Martínez-Flórez

TL;DR: The suitability of quercetin as a therapeutic approach for obesity‐associated NAFLD via its anti‐inflammatory, antioxidant and prebiotic integrative response is supported.

TL;DR: Although results from different studies have demons- trated that flavonoids can act as pro-oxidant at very high doses, most investigations have reported anti-in- flammatory, antiviral, or anti-allergic effects and a pro- tective role in heart diseases, cancer and different patho- logies.

TL;DR: Findings support the view that the mechanism of action is via inhibition of IL-1beta-induced NF-kappaB activation, and quercetin, a natural flavonol widely distributed in the human diet, inhibits NO production in IL- 1beta-stimulated hepatocytes through the inhibition of iNOS expression.

TL;DR: Although results from different studies have demonstrated that flavonoids can act as pro-oxidant at very high doses, most investigations have reported anti-inflammatory, antiviral, or anti-allergic effects and a protective role in heart diseases, cancer and different pathologies.

TL;DR: Results place quercetin as a potential therapeutic strategy for preventing NAFLD progression by attenuating gene expression deregulation, at least in part through PI3K/AKT pathway inactivation.