S
Svitlana Prylutska
Researcher at Taras Shevchenko National University of Kyiv
Publications - 100
Citations - 1739
Svitlana Prylutska is an academic researcher from Taras Shevchenko National University of Kyiv. The author has contributed to research in topics: Chemistry & Lewis lung carcinoma. The author has an hindex of 25, co-authored 90 publications receiving 1462 citations. Previous affiliations of Svitlana Prylutska include National University of Life and Environmental Sciences of Ukraine.
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Journal ArticleDOI
Application of C60 Fullerene-Doxorubicin Complex for Tumor Cell Treatment In Vitro and In Vivo.
R. R. Panchuk,Svitlana Prylutska,V V Chumakl,N. R. Skorokhyd,L. V. Lehka,Maxim P. Evstigneev,Yu. I. Prylutskyy,Walter Berger,Petra Heffeter,Peter Scharff,Uwe Ritter,Rostyslav Stoika +11 more
TL;DR: It was found that Dox conjugation with C60 fullerene leads to 1.5-2-fold increase in Dox toxicity towards various human tumor cell lines, compared with such effect when the drug is used alone.
Journal ArticleDOI
Anti-oxidant Properties of C60 Fullerenes in vitro
Svitlana Prylutska,I. I. Grynyuk,O. P. Matyshevska,Yu. I. Prylutskyy,Uwe Ritter,Peter Scharff +5 more
TL;DR: C60 fullerenes at concentration 10−5 M show a protective effect on apoptotic H2O2–treated thymocytes, restoring the level of GSH in cytoplasm and increasing the activity of electron‐transport chain in mitochondria.
Journal ArticleDOI
C60 Fullerene as Synergistic Agent in Tumor-Inhibitory Doxorubicin Treatment
Svitlana Prylutska,I. I. Grynyuk,O. P. Matyshevska,Yuriy Prylutskyy,Maxim P. Evstigneev,Peter Scharff,Uwe Ritter +6 more
TL;DR: C60 fullerene demonstrated a protective effect against superoxide dismutase and glutathione peroxidase inhibition induced by Dox-dependent oxidative insult in the liver and heart and is considered to be a promising approach for cancer chemotherapy.
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C60 fullerene enhances cisplatin anticancer activity and overcomes tumor cell drug resistance
Svitlana Prylutska,R. R. Panchuk,Grzegorz Gołuński,Larysa Skivka,Yuriy Prylutskyy,Vasyl V. Hurmach,Nadya Skorohyd,Agnieszka Borowik,Anna Woziwodzka,Jacek Piosik,O. A. Kyzyma,Vasil M. Garamus,Leonid A. Bulavin,Maxim P. Evstigneev,Anatoly S. Buchelnikov,Rostyslav Stoika,Walter Berger,Uwe Ritter,Peter Scharff +18 more
TL;DR: The C60+Cis complex effectively induced tumor cell death in vitro and inhibited tumor growth in vivo, overcoming drug resistance likely by the potential of the C60 fullerene to interact with P-gp, MRp-1, and MRP-2 molecules.
Journal ArticleDOI
Complex of C60 Fullerene with Doxorubicin as a Promising Agent in Antitumor Therapy.
Svitlana Prylutska,Larysa Skivka,Gennadiy V. Didenko,Yuriy Prylutskyy,Maxim P. Evstigneev,Grygoriy P. Potebnya,R. R. Panchuk,Rostyslav Stoika,Uwe Ritter,Peter Scharff +9 more
TL;DR: It was found that volume of tumor from mice treated with the C60 + Dox complex was 1.4 times less than that in control untreated animals and the treatment of tumor-bearing mice was accompanied by the increase of cytotoxic activity of immune cells.