Bridging the gap between the ancient art of herbalism and the emerging sciences of ethnopharmocology and phytopharmacotherapy, this book highlights the major breakthroughs in the history of the field and focuses on future directions in the discovery and application of herb-derived medicines. Implementing the concept of reverse pharmacology, it inte

Herbalism, Phytochemistry And Ethnopharmacology

In this study, we examined the effect of the Maharishi Ayur-Veda herbal mixtures (MAHMs) Maharishi Amrit Kalash-4 and -5 (M-4 and M-5), MA-631, and Maharishi Coffee Substitute (MCS) on low-density lipoprotein (LDL) oxidation and compared the potency of these mixtures to ascorbic acid, α-tocopherol, and probucol. LDL was incubated in 95% air and 5% CO2, with or without 3 μM Cu+2, in the presence or absence of MAHMs, for 6 or 24 h. In a separate experiment, LDL was incubated as above except MAHMs were added at 0, 1.5, and 3.5 h after incubation started to assess their effect on initiation and propagation of LDL oxidation. Our results demonstrate that MAHMs caused concentration-dependent inhibition of LDL oxidation as assessed by thiobarbituric acid-reactive substances and electrophoretic mobility. The MAHM showed more antioxidant potency in preventing LDL oxidation than ascorbic acid, α-tocopherol, or probucol. Also, MAHMs inhibited both initiation and propagation of cupric ion-catalyzed LDL oxidation. These results suggest the importance of further research on these herbal mixtures in the investigation of atherosclerosis and free radical-induced injury.

Inhibition of human low-density lipoprotein oxidation in vitro by Maharishi Ayur-Veda herbal mixtures.

The purpose of this review is to provide comprehensive and relevant information on the utilization and pharmacological activities of Strychnos nux-vomica Linn. (Loganiaceae), used for the treatment of various diseases. Strychnos nux-vomica is an evergreen tree native to Southeast Asia and its dried seeds are used for the treatment of neurodisorders, arthritis and vomiting. The different use of this plant as herbal remedy in Chinese medicine is also reported in the literature. Strychnine and brucine are major pharmacologically active phytoconstituents of Strychnos nux-vomica, which are central nervous stimulant, but also found to be poisonous at high dosage. Owing to its diversity of phytoconstituents, it is used for treatment of various disorders. Pharmacologically it has been validated for its effect on inflammation, microbial infections, gastrointestinal problem, nervous system, bones cells, cardiovascular systems, cancer and blood glucose level. It also has antioxidant activity and antifeedant activity. Informations about Strychnos nux-vomica, compiled in the present review article could be useful to the researchers for the scientific validation of its traditional claim in the future.

A review on medicinal uses, analytical techniques and pharmacological activities of Strychnos nux-vomica Linn.: A concise report.

A B ST R A C T Strychnos potatorum (Clearing nut), an important medicinal plant used in the traditional and folk medicine for treating several aliments including microbial infections, diarrhoea and diabetes. Some of its pharmacognostic studies such as fluorescent, organoleptic, ash and mineral contents of root, stem bark and seed (both collected and market) , and GC- alkaloid profiles of seed have been investigated. Considerable colour variations in the fluorescent behaviour of raw drugs were observed. The highest yields were obtained for the aqueous extracts followed by ethanol, petroleum ether and chloroform extracts. The colour of the extracts thus obtained have from ivory to dark brown and bitter to pungent bitter in taste. Higher values of the total ash and insoluble acid contents were recorded for the stem bark, followed by root and seed samples. Considerable amounts of iron and copper found in all parts of the plant. However, lead, a toxic element was found in trace amount in the market seed sample. Further, the GC-alkaloid profiles of seed samples have shown significant variation in terms of percent area of peaks. Furthermore, the co-TLC study has revealed the absence of strychnine and brucine from the seed sample.

Pharmacognostic Studies of Strychnos potatorum L.f.

The bark of Strychnos potatorum L. (Loganiaceae), is used as an adulterant of S. nux-vomica L. The latter is highly poisonous, containing the alkaloids strychnine and brucine, whereas the former is nonpoisonous. The two barks could be distinguished by pharmacognostic evaluation.

Swapna Chakraborti

Papers

Comparative Pharmacognosy of Strychnos nux-vomica and Strychnos potatorum Stem Barks