Swati R. Mujumdar

TL;DR: Ten carboxymethylindocyanine dyes which form the basis of a new series of fluorescent probes have been synthesized and converted into succinimidyl active esters for fluorescent labeling of proteins or other amino-containing substances and the use of values of chromophore-equivalent weight (W/Ceq), calculated from quantitative absorption data on dye samples, is proposed.

TL;DR: New isothiocyanate derivatives of cyanine dyes were synthesized as fluorescent covalent labeling reagents for proteins and other biomolecules, expanding the possibilities of multicolor analyses.

TL;DR: A synthetic method for shifting the absorption and emission wavelengths of cyanine dye labels by 15-30 nm to the red has been developed, significantly increases the potential for preparing fluorescent probes for multiparameter analysis in cytometry and diagnostics.

TL;DR: The synthesis of two new cyanine dye-labeled dUTP analogs, Cy3-dUTP and Cy5-d UTP are described, which are efficient substrates for DNA polymerases and can be incorporated into DNA probes by standard nick translation, random priming and polymerase chain reactions.

TL;DR: Conjugated antibody was injected, and mice were imaged immediately after injection and at appropriate intervals thereafter using a standard camera lens, dissecting microscope, or endoscopes to support the possibility of visualizing tumor metastasis by optical means, including currently available endoscope.