T
T. Alwyn Jones
Researcher at Uppsala University
Publications - 72
Citations - 6824
T. Alwyn Jones is an academic researcher from Uppsala University. The author has contributed to research in topics: Active site & Enzyme. The author has an hindex of 39, co-authored 71 publications receiving 6476 citations. Previous affiliations of T. Alwyn Jones include Max Planck Society & University of Würzburg.
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The sequence, crystal structure determination and refinement of two crystal forms of lipase B from Candida antarctica.
TL;DR: The structure of Candida antarctica lipase B shows that the enzyme has a Ser-His-Asp catalytic triad in its active site, which accounts for the substrate specificity and high degree of stereospecificity of this lipase.
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A synthetic IgG-binding domain based on staphylococcal protein A
Björn Nilsson,Tomas Moks,Birger Jansson,Lars Abrahmsén,Anette Elmblad,Erik Holmgren,Christina Henrichson,T. Alwyn Jones,Mathias Uhlén +8 more
TL;DR: In this paper, a synthetic IgG-binding domain based on staphylococcal protein A was designed with the aid of sequence comparisons and computer graphic analysis to overcome the difficulties of introducing site-specific changes into the repetitive gene.
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Phi/psi-chology: Ramachandran revisited
TL;DR: The errors that can be introduced into a protein model during model building and refinement vary tremendously in their importance and severity, and for a structure built into an experimental map, the main ones are limited resolution and poorly phased diffraction data.
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The Uppsala Electron-Density Server
TL;DR: An account is provided of the methods that are used to generate the information contained in the Uppsala Electron Density Server and some of the problems that are encountered in the map-generation process.
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Between objectivity and subjectivity
TL;DR: Protein crystallography is an exacting trade, and the results may contain errors that are difficult to identify.