T. Brill

TL;DR: Magnetofection is nucleic acid delivery to cells supported and site-specifically guided by the attractive forces of magnetic fields acting on nucleic acids shuttles (vectors) which are associated with magnetic nanoparticles as discussed by the authors.

TL;DR: Indocyanine green fluoroscopy is a useful tool to evaluate perfusion topographically and predict necrosis and from a statistical point of view a perfusion index of less than 25% of the reference skin can be considered as a sign of developing flap necrosis.

TL;DR: Adenoviral gene transfer of the V2R into the myocardium increases cardiac contractility in vivo and could lead to novel strategies in the therapy of congestive heart failure by bypassing the desensitized beta-adrenergic receptor-signaling cascade.

TL;DR: Using an adenoviral vector, HSV1-tk can be successfully expressed in cardiac cells in vitro and in vivo, yielding high uptake of radiolabeled FIAU and suggesting that imaging transgene expression in the heart is feasible and may be used to monitor gene therapy noninvasively.

TL;DR: This phase I dose‐escalation study was performed to determine toxicity and feasibility of gene therapy with feline granulocyte‐macrophage colony‐stimulating factor (feGM‐CSF) in cats with fibrosarcomas and found 1250 µg of feGM‐ CSF plasmid DNA applied by magnetofection is safe and feasible for phase II testing.