T
T. D. Allen
Publications - 8
Citations - 3492
T. D. Allen is an academic researcher. The author has contributed to research in topics: Stromal cell & Stem cell. The author has an hindex of 7, co-authored 8 publications receiving 3463 citations.
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Journal ArticleDOI
Conditions controlling the proliferation of haemopoietic stem cells in vitro.
TL;DR: A liquid culture system is described whereby proliferation of haemopoietic stem cells, production of granulocyte precursor cells (CFU‐C), and extensive granulopoiesis can be maintained in vitro for several months.
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Heparan sulphate bound growth factors: a mechanism for stromal cell mediated haemopoiesis.
TL;DR: It is clearly demonstrate that the major sulphated glycosaminoglycan of mouse marrow stroma, heparan sulphate4, possesses the ability to adsorb both GM-CSF and the multilineage haemopoietic growth factor, Interleukin 3 (IL-3).
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Stimulation of differentiation and proliferation of haemopoietic cells in vitro.
TL;DR: There was a 2 X enhancement of monolayer colony development compared with the combined total present in the (marrow alone) plus (thymus alone) cultures, and better maintenance of non‐attaching cells was seen in the co‐cultures.
Journal Article
Long-term marrow culture: an overview of techniques and experience
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Metabolically inactive 3T3 cells can substitute for marrow stromal cells to promote the proliferation and development of multipotent haemopoietic stem cells.
TL;DR: It is suggested that the ability of FACS‐CFU‐S and FDCP‐Mix cells to respond to 3T3 cells involves specific ligand/receptor interactions.