T
T. Ebendal
Researcher at Karolinska Institutet
Publications - 20
Citations - 1580
T. Ebendal is an academic researcher from Karolinska Institutet. The author has contributed to research in topics: Nerve growth factor & Neurotrophin. The author has an hindex of 13, co-authored 20 publications receiving 1572 citations. Previous affiliations of T. Ebendal include Uppsala University.
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Molecular cloning and neurotrophic activities of a protein with structural similarities to nerve growth factor: developmental and topographical expression in the brain.
TL;DR: A pool of degenerate oligonucleotides representing all possible codons in regions of homology between brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) to prime rat hippocampal cDNAs to represent a family of neurotrophic factors that may cooperate to support the development and maintenance of the vertebrate nervous system.
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Chronic implants of chromaffin tissue into the dopamine-denervated striatum. Effects of NGF on graft survival, fiber growth and rotational behavior
TL;DR: It is concluded that implantation of chromaffin tissue into striatum in conjunction with NGF treatments is an effective means of counteracting some of the symptoms of experimentally induced unilateral parkinsonism in rats.
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Chimeric molecules with multiple neurotrophic activities reveal structural elements determining the specificities of NGF and BDNF.
TL;DR: The results show that the biological specificities of the two proteins are obtained by specific combinations of a set of sequences that differ between the two molecules.
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Rescue of basal forebrain cholinergic neurons after implantation of genetically modified cells producing recombinant NGF
TL;DR: It is suggested that implantation of genetically modified cells producing NGF may have therapeutic applications in rescuing damaged central cholinergic neurons in senile dementia of the Alzheimer type as well as in providing trophic support for chromaffin tissue grafts in Parkinson's disease.
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Regulation of beta-nerve growth factor expression by inflammatory mediators in hippocampal cultures.
TL;DR: In embryonic rat: hippocampal cultures containing both neurons and glial cells, a variety of immunomodulators regulate NGF expression in the hippocampus, and agents which promote inflammatory activity appear to increase NGFexpression.