T
T.–I. Chikama
Researcher at University of Cincinnati
Publications - 7
Citations - 262
T.–I. Chikama is an academic researcher from University of Cincinnati. The author has contributed to research in topics: Corneal epithelium & Lumican. The author has an hindex of 4, co-authored 7 publications receiving 249 citations. Previous affiliations of T.–I. Chikama include Yamaguchi University.
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Journal ArticleDOI
Response of Lens Epithelial Cells to Injury: Role of Lumican in Epithelial-Mesenchymal Transition
Shizuya Saika,Takeshi Miyamoto,Sai-ichi Tanaka,Takeshi Tanaka,Iku Ishida,Yoshitaka Ohnishi,Akira Ooshima,Toshiyuki Ishiwata,Goro Asano,T.–I. Chikama,Atsushi Shiraishi,Chia-Yang Liu,Candace W.-C. Kao,Winston W.-Y. Kao +13 more
TL;DR: Human capsular opacification contains lumican, and mouse LECs upregulate lumican and alphaSMA in response to injury, indicating that lumican may modulate injury-induced EMT in LECS.
Journal ArticleDOI
Lumican is required for neutrophil extravasation following corneal injury and wound healing.
Yasuhito Hayashi,Mindy K. Call,T.–I. Chikama,Hongshan Liu,Eric C. Carlson,Yan Sun,Eric Pearlman,James L. Funderburgh,George F. Babcock,Chia-Yang Liu,Yuichi Ohashi,Winston W.-Y. Kao +11 more
TL;DR: The role of lumican is addressed in the process of extravasation of polymorphonuclear leukocytes (PMNs) during the early inflammatory phase present in the healing of the corneal epithelium following debridement, consistent with the notion that in addition to regulating the collagen fibril architecture, lumican acts to aid neutrophil recruitment and invasion following corneAL damage and inflammation.
Journal ArticleDOI
Excess FGF-7 in corneal epithelium causes corneal intraepithelial neoplasia in young mice and epithelium hyperplasia in adult mice.
T.–I. Chikama,Chia-Yang Liu,Johanna T A Meij,Yasuhito Hayashi,Yasuhito Hayashi,I-Jong Wang,Liu Yang,Teruo Nishida,Winston W.-Y. Kao +8 more
TL;DR: Taken together, Krt12-rtTA/tet-O-FGF-7 mice may be a suitable animal model for the study of the molecular and cellular mechanisms of human OSSN.
Journal ArticleDOI
Characterization of tetracycline-inducible bitransgenic Krt12rtTA/+/tet-O-LacZ mice.
T.–I. Chikama,Yasuhito Hayashi,Chia-Yang Liu,Noriko Terai,Kazuto Terai,Candace W.-C. Kao,L. Wang,M. Hayashi,Teruo Nishida,Philip Sanford,Tom Doestchman,Winston W.-Y. Kao +11 more
TL;DR: A binary mouse model has been successfully established that conditionally overexpresses reporter genes in corneal epithelium and will be useful in elucidating signaling pathways of various growth factors and cytokines and gene functions in the maintenance of homeostasis and pathogenesis in the adult mouse cornea.