This work was supported by the Foundation for Science and Technology (FCT), Portugal (projects PTDC/QUI-QUI/113687/2009 and PEst-C/QUI/UI0081/2013). A.G. (SFRH/BD/43531/2008) and M.J.M. (SFRH/BD/61262/2009) thank FCT for grants.

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Chromone: A Valid Scaffold in Medicinal Chemistry

Palladium(II)-Catalyzed Direct Intermolecular Alkenylation of Chromones

An asymmetric inverse-electron-demand Diels–Alder reaction of chromone-fused dienes and β,β-disubstituted α,β-unsaturated aldehydes has been developed via dienamine catalysis. Different domino or sequential transformations could be carried out for electron-deficient dienes with variously substituted patterns, allowing for the efficient construction of caged or fused tetrahydroxanthones with high molecular complexity and skeletal diversity in excellent diastereo- and enantioselectivities.

Asymmetric Diels–Alder reaction of β,β-disubstituted enals and chromone-fused dienes: construction of collections with high molecular complexity and skeletal diversity

Chemistry of 4-Oxo-4H-[1]benzopyran-3-carboxaldehyde

A chromone analog inhibits TNF-alpha induced expression of cell adhesion molecules on human endothelial cells via blocking NF-kappaB activation.

The syntheses of trans-3-(4-oxo-4H-1-benzypyran-3)acrylic acid and a number of analogs shown to be highly active in antiallergic bioassays are described. These compounds are of possible value in the treatment of asthma. The structural requirements for biological activity are discussed with reference to the type of the substituents on the chromone ring or positions of linkage of the acrylic acid on the pyrone ring.

Studies on antianaphylactic agents. 4. Synthesis and structure-activity relationships of 3-(4-oxo-4H-1-benzopyran-3)acrylic acids, a new series of antiallergic substances, and some related compounds

Studies on antianaphylactic agents part 4, synthesis and structure-activity relationships of 3-(4-oxo-4h-1-benzopyran-3)acrylic acids, a new series of antiallergic substances, and some related compounds

T. Murata

Papers

Studies on antianaphylactic agents. 4. Synthesis and structure-activity relationships of 3-(4-oxo-4H-1-benzopyran-3)acrylic acids, a new series of antiallergic substances, and some related compounds

Studies on antianaphylactic agents part 4, synthesis and structure-activity relationships of 3-(4-oxo-4h-1-benzopyran-3)acrylic acids, a new series of antiallergic substances, and some related compounds