T
T Shimada
Researcher at Vanderbilt University
Publications - 1
Citations - 312
T Shimada is an academic researcher from Vanderbilt University. The author has contributed to research in topics: Carcinogen & Enzyme. The author has an hindex of 1, co-authored 1 publications receiving 311 citations.
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Evidence for cytochrome P-450NF, the nifedipine oxidase, being the principal enzyme involved in the bioactivation of aflatoxins in human liver.
T Shimada,F P Guengerich +1 more
TL;DR: In vitro studies with human liver indicate that the major catalyst involved in the bioactivation of the hepato-carcinogen aflatoxin B1 to its genotoxic 2,3-epoxide derivative is cytochrome P-450NF, a previously characterized protein that also catalyzes the oxidation of nifedipine and other dihydropyridines, quinidine, macrolide antibiotics, various steroids, and other compounds.