T
Tadashi Katoh
Researcher at Tohoku Pharmaceutical University
Publications - 191
Citations - 2439
Tadashi Katoh is an academic researcher from Tohoku Pharmaceutical University. The author has contributed to research in topics: Total synthesis & Enantioselective synthesis. The author has an hindex of 30, co-authored 191 publications receiving 2315 citations. Previous affiliations of Tadashi Katoh include Osaka University & Tokyo Institute of Technology.
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Synthetic studies of huperzine A and its fluorinated analogues. 1. Novel asymmetric syntheses of an enantiomeric pair of huperzine A
TL;DR: In this article, an enantiomeric pair of huperzine A was synthesized by employing two types of methods which feature the tandem Cinchona alkaloids-promoted asymmetric Michael addition / aldol reaction of the β-keto ester 3 with methacrolein (4) (max 64% ee, 3+4→5, Scheme 2) and the asymmetric bicycloannulation of 3 with 2-methylene-1,3-propanediol diacetate (7) catalyzed by palladium cataly
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Total Synthesis of the Bicyclic Depsipeptide HDAC Inhibitors Spiruchostatins A and B, 5′′‐epi‐Spiruchostatin B, FK228 (FR901228) and Preliminary Evaluation of Their Biological Activity
Koichi Narita,Takuya Kikuchi,Kazuhiro Watanabe,Toshiya Takizawa,Takamasa Oguchi,Kyosuke Kudo,Keisuke Matsuhara,Hideki Abe,Takao Yamori,Minoru Yoshida,Tadashi Katoh +10 more
TL;DR: The bicyclic depsipeptide histone deacetylase (HDAC) inhibitors spiruchostatins A and B, 5''-epi-spiruchostatin B and FK228 were efficiently synthesized in a convergent and unified manner and established the C5'' stereochemistry of spiruchstatin B.
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Total synthesis of natural (+)-FR900482. 2. Efficient syntheses of the aromatic and the optically active aliphatic fragments
TL;DR: In this paper, the synthesis of the aromatic fragment 4 was achieved starting from commercially available 5-hydroxy-isophthalic acid (6) by utilizing Claisen rearrangement of 9, bromolactonization of 12, and modified Curtius rearrangements of 16 as key steps.
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Iridium-catalyzed oxidative lactonization and intramolecular Tishchenko reaction of δ-ketoaldehydes for the synthesis of isocoumarins and 3,4-dihydroisocoumarins
TL;DR: Two new cyclizations of ketoaldehydes have been developed using an Ir-ligand bifunctional catalyst and afforded 3,4-dihydroisocoumarins in good yields.
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Highly efficient total synthesis of the marine natural products (+)-avarone, (+)-avarol, (-)-neoavarone, (-)-neoavarol and (+)-aureol.
Junji Sakurai,Takamasa Oguchi,Kazuhiro Watanabe,Hideki Abe,Syu-ichi Kanno,Masaaki Ishikawa,Tadashi Katoh +6 more
TL;DR: An in vitro cytotoxicity assay of compounds 1-5 against human histiocytic lymphoma cells U937 determined the order of cytotoxic potency and some novel aspects of structure-activity relationships.