Tailoi Chan-Ling

TL;DR: It is proposed that hypoxia caused by the onset of neuronal activity is detected by strategically located populations of neuroglia, first astrocytes, then Muller cells, and in response they secrete VEGF, inducing formation of the superficial and deep layers of retinal vessels, respectively.

TL;DR: The results are the first to show a significant decline in intracellular NAD+ levels and NAD∶NADH ratio in all organs by middle age compared to young rats, and suggest that adequate NAD+ concentrations may be an important longevity assurance factor.

TL;DR: The cellular and physiological mechanisms responsible for the regulation of blood flow in the retina and choroid in health and disease are reviewed and the role of capillaries, astrocytes and pericytes in regulating blood flow is discussed.

TL;DR: Regulation of VEGF by tissue oxygen mediates the inhibition of vessel growth during hyperoxia and the subsequent proliferative vasculopathy.

TL;DR: Observed mechanisms of retinal vascularization appear similar to those of vascularization of the central nervous system during development, and suggest that the formation of primordial vessels in the central retina is mediated by vasculogenesis, whereas angiogenesis is responsible for increasing vascular density and peripheral vascularization in the inner retina.