T
Takao Tobe
Researcher at Johns Hopkins University
Publications - 8
Citations - 1668
Takao Tobe is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: Vascular endothelial growth factor & Neovascularization. The author has an hindex of 7, co-authored 8 publications receiving 1624 citations. Previous affiliations of Takao Tobe include Johns Hopkins University School of Medicine.
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Journal Article
Transgenic mice with increased expression of vascular endothelial growth factor in the retina: a new model of intraretinal and subretinal neovascularization.
Naoyuki Okamoto,Takao Tobe,Sean F. Hackett,Hiroaki Ozaki,Melissa A. Vinores,William J. LaRochelle,Donald J. Zack,Peter A. Campochiaro +7 more
TL;DR: In this article, the authors investigated the effect of increased VEGF expression in the retina using tissue-specific, gain-of-function transgenic mice in which the bovine rhodopsin promoter is coupled to the gene for human vascular endothelial growth factor.
Journal ArticleDOI
Transgenic Mice with Increased Expression of Vascular Endothelial Growth Factor in the Retina: A New Model of Intraretinal and Subretinal Neovascularization.
Naoyuki Okamoto,Takao Tobe,Sean F. Hackett,Hiroaki Ozaki,Melissa A. Vinores,W La Rochelle,Donald J. Zack,Peter A. Campochiaro +7 more
TL;DR: It is demonstrated that over-expression of VEGF in the retina is sufficient to cause intraretinal and subretinal NV and provides a valuable new animal model.
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Targeted disruption of the FGF2 gene does not prevent choroidal neovascularization in a murine model
Takao Tobe,Sagrario Ortega,J. D. Luna,Hiroaki Ozaki,Naoyuki Okamoto,Nancy L. Derevjanik,Stanley A. Vinores,Claudio Basilico,Peter A. Campochiaro +8 more
TL;DR: It is demonstrated that FGF2 is not required for the development of CNV after laser-induced rupture of Bruch's membrane and provides a new model to investigate molecular mechanisms and anti-angiogenic therapy in CNV.
Journal Article
Evolution of neovascularization in mice with overexpression of vascular endothelial growth factor in photoreceptors.
Takao Tobe,Naoyuki Okamoto,Melissa A. Vinores,Nancy L. Derevjanik,Stanley A. Vinores,Donald J. Zack,Peter A. Campochiaro +6 more
TL;DR: Data support the feasibility of using rhodopsin-VEGF transgenic mice to study tissue-specific aspects of NV in the retina and to test antiangiogenic agents for inhibition of intraretinal and subretinal NV.
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Blood-retinal barrier (BRB) breakdown in experimental autoimmune uveoretinitis: comparison with vascular endothelial growth factor, tumor necrosis factor alpha, and interleukin-1beta-mediated breakdown.
J. D. Luna,Chi Chao Chan,Nancy L. Derevjanik,Jeremy Mahlow,Charlie Chiu,Bo Peng,Takao Tobe,Peter A. Campochiaro,Stanley A. Vinores +8 more
TL;DR: It is shown that VEGF, TNFα, and IL‐1β each cause BRB breakdown by opening tight junctions between RVE cells and possibly by increasing transendothelial vesicular transport.