Takashi Iwase

TL;DR: MSC transplantation improved cardiac function in a rat model of DCM, possibly through induction of myogenesis and angiogenesis, as well as by inhibition of myocardial fibrosis.

TL;DR: Results suggest that intravenous administration of MSCs improves cardiac function after acute myocardial infarction through enhancement of angiogenesis and myogenesis in the ischemic myocardium.

TL;DR: Compared with MNC, MSC survived well under an ischemic environment, and differentiated into not only endothelial cells but also vascular smooth muscle cells, suggesting that MSC transplantation may be a new therapeutic strategy for the treatment of severe peripheral vascular disease.

TL;DR: Combination therapy with oral sildenafil and beraprost attenuates the development of MCT-induced pulmonary hypertension compared with treatment with each drug alone, resulting in further improvement in pulmonary hemodynamics.

TL;DR: A combination of AM infusion and M NC transplantation caused significantly greater improvement in hindlimb ischemia than MNC transplantation alone, and this effect may be mediated in part by the angiogenic potency of AM itself and the beneficial effects of AM on the survival, adhesion, and differentiation of transplanted MNCs.