T
Takuo Tsukuda
Researcher at Hoffmann-La Roche
Publications - 8
Citations - 311
Takuo Tsukuda is an academic researcher from Hoffmann-La Roche. The author has contributed to research in topics: Chemical synthesis & Chemical stability. The author has an hindex of 5, co-authored 8 publications receiving 311 citations.
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Patent
Nucleoside derivatives for the treatment of hepatitis c
Rene Devos,Brian William Dymock,Christopher John Hobbs,Wen-Rong Jiang,Martin Joseph Armstrong,John Herbert Merrett,Isabel Najera,Nobuo Shimma,Takuo Tsukuda +8 more
TL;DR: The use of compounds of formula (I) is defined in this paper, where the use of I is defined as the mixture of two or more carbon atoms, each of which is substituted with four different substituents.
Patent
4'-substituted nucleosides for the treatment of diseases mediated by the hepatitis C virus
Rene Devos,Christopher John Hobbs,Wen-Rong Jiang,Martin Joseph Armstrong,John Herbert Merrett,Isabel Najera,Nobuo Shimma,Takuo Tsukuda +7 more
TL;DR: In this article, the use of nucleoside derivatives of Formula (I) for the treatment of diseases mediated by the hepatitis C Virus (HCV), for the preparation of a medicament for such treatment and to pharmaceutical compositions containing such compounds.
Journal ArticleDOI
Modeling, synthesis and biological activity of novel antifungal agents (1)
Takuo Tsukuda,Yasuhiko Shiratori,Masami Watanabe,Hitomi Ontsuka,Kazuo Hattori,Michio Shirai,Nobuo Shimma +6 more
TL;DR: Homology modeling of candida lanosterol C-14 demethylase, synthesis and in vitro antifungal activities of cyclohexyl analogs of restricticin are described.
Journal ArticleDOI
Synthesis of restrictinol and 9,10,11,12-tetrahydro-7-desmethylrestricticin
TL;DR: Restrictinol 2 and 9, 10, 11, 12-tetrahydro-7desmethylrestricticin (Ro 09-1571) have been synthesized from L-glucose.
Journal ArticleDOI
Synthesis of cyclohexyl analogs of restricticin
TL;DR: Synthesis of cyclohexyl analogs of restricticin, a novel type of antifungal agent from ⊂-) R-carvone and their in vitro antIFungal activity are described.