T
Tambudzai Kanhema
Researcher at University of Bergen
Publications - 15
Citations - 1360
Tambudzai Kanhema is an academic researcher from University of Bergen. The author has contributed to research in topics: Dentate gyrus & Long-term potentiation. The author has an hindex of 8, co-authored 13 publications receiving 1243 citations.
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Journal ArticleDOI
Sustained Arc/Arg3.1 Synthesis Controls Long-Term Potentiation Consolidation through Regulation of Local Actin Polymerization in the Dentate Gyrus In Vivo
Elhoucine Messaoudi,Tambudzai Kanhema,Jonathan Soule,Adrian Tiron,Girstaute Dagyte,Bruno M. da Silva,Clive R. Bramham +6 more
TL;DR: Results couple activity-induced expression of Arc to expansion of the actin cytoskeleton underlying enduring LTP, identifying Arc as a key molecular effector of BDNF in synaptic plasticity.
Journal ArticleDOI
Brain-Derived Neurotrophic Factor Triggers Transcription-Dependent, Late Phase Long-Term Potentiation In Vivo
TL;DR: A role for BDNF in triggering transcription-dependent, late phase LTP in the intact adult brain is supported and is associated with enhancement in both synaptic strength and granule cell excitability (EPSP–spike coupling).
Journal ArticleDOI
Chronic mild stress inhibits BDNF protein expression and CREB activation in the dentate gyrus but not in the hippocampus proper
Janne Grønli,Clive R. Bramham,Robert Murison,Tambudzai Kanhema,Eldbjørg Fiske,Bjørn Bjorvatn,Bjørn Bjorvatn,Reidun Ursin,Reidun Ursin,Chiara M. Portas,Chiara M. Portas +10 more
TL;DR: The results couple chronic mild stress to a downregulation of CREB activity and BDNF protein expression specifically within the dentate gyrus and support the possibility that the BDNF-CREB system plays an important role in the response to environmental challenges.
Journal ArticleDOI
Dual regulation of translation initiation and peptide chain elongation during BDNF-induced LTP in vivo: evidence for compartment-specific translation control.
Tambudzai Kanhema,Grethe Dagestad,Debabrata Panja,Adrian Tiron,Elhoucine Messaoudi,Bjarte Håvik,Shui-Wang Ying,Angus C. Nairn,Nahum Sonenberg,Clive R. Bramham +9 more
TL;DR: The results suggest a compartment‐specific regulation in which initiation is selectively enhanced by BDNF at synapses, while both initiation and elongation are modulated at non‐synaptic sites.
Journal ArticleDOI
Balancing Arc Synthesis, mRNA Decay, and Proteasomal Degradation MAXIMAL PROTEIN EXPRESSION TRIGGERED BY RAPID EYE MOVEMENT SLEEP-LIKE BURSTS OF MUSCARINIC CHOLINERGIC RECEPTOR STIMULATION
Jonathan Soule,Maria Nordheim Alme,Craig Myrum,Manja Schubert,Tambudzai Kanhema,Clive R. Bramham +5 more
TL;DR: The results demonstrate dynamic, multifaceted control of Arc synthesis during mAchR signaling, and implicate cholinergic epoch duration and repetition as critical determinants of Arc expression and function in synaptic plasticity and behavior.