http://www.zoranvolleyart.si/images/Mango/01.pdf

Medicinal properties of mangosteen (Garcinia mangostana).

As part of ongoing research on cancer chemopreventive agents from botanical dietary supplements, Garcinia mangostana L. (commonly known as mangosteen) was selected for detailed study. Repeated chromatography of a CH2Cl2-soluble extract of the pericarp led to the isolation of two new highly oxygenated prenylated xanthones, 8-hydroxycudraxanthone G (1) and mangostingone [7-methoxy-2-(3-methyl-2-butenyl)-8-(3-methyl-2-oxo-3-butenyl)-1,3,6-trihydroxyxanthone, 2], together with 12 known xanthones, cudraxanthone G (3), 8-deoxygartanin (4), garcimangosone B (5), garcinone D (6), garcinone E (7), gartanin (8), 1-isomangostin (9), α-mangostin (10), γ-mangostin (11), mangostinone (12), smeathxanthone A (13), and tovophyllin A (14). The structures of compounds 1 and 2 were elucidated by spectroscopic data analysis. Except for compound 2, which was isolated as a minor component, the antioxidant activities of all isolates were determined using authentic and morpholinosydnonimine-derived peroxynitrite methods, and comp...

/pdf/antioxidant-xanthones-from-the-pericarp-of-garcinia-4y9pfpqh0g.pdf

Antioxidant Xanthones from the Pericarp of Garcinia mangostana (Mangosteen)

https://www.repositorio.ufop.br/bitstream/123456789/805/6/ARTIGO_TrioxygenatedNaturallyOccurring.pdf

Tetraoxygenated naturally occurring xanthones

Garcinia mangostana L. (mangosteen, Clusiaceae) has a long history of use as a medical plant, mostly in Southeast Asia. This is a review of the phytochemistry and pharmacology of mangosteen. Traditionally mangosteen is famous for its antiinflammatory properties and is used in the treatment of skin infections and wounds. Other applications include the therapy of various conditions such as dysentery, different urinary disorders, cystitis and gonorrhoea. This review highlights the development of this botanical drug into a widely used nutraceutical. Products derived from G. mangostana are now distributed increasingly all over the world. This has given rise to a concomitant increase in research on the phytochemical constituents and biological activity of mangosteen. Central to the biological activity of the species are xanthones which are reviewed in detail. A comprehensive assessment of the biological activities of individual xanthones as well as extracts of G. mangostana is included. In addition, its potential in terms of developing novel drug leads is assessed. Products containing its fruits are now sold widely as 'liquid botanical supplements', but evidence for the health benefits of these products is still lacking. As shown here, a serious weakness in our knowledge is the lack of clinical data and it is not yet clear to what extent the findings about pharmacological activities are of potential clinical relevance.

Garcinia mangostana L.: a phytochemical and pharmacological review

Garcinol, harvested from Garcinia indica, has traditionally been used in tropical regions and appreciated for centuries; however its biological properties are only beginning to be elucidated. There is ample data to suggest potent antioxidant properties of this compound which have been used to explain most of its observed biological activities. However, emerging evidence suggests that garcinol could be useful as an anti-cancer agent, and it is increasingly being realized that garcinol is a pleiotropic agent capable of modulating key regulatory cell signaling pathways. Here we have summarized the progress of our current research knowledge on garcinol and its observed biological activities. We have also provided an explanation of observed properties based on its chemical structure and provided an insight into the structure and properties of chalcones, the precursors of garcinol. The available data is promising but more detailed investigations into the various properties of this compound, particularly its anti-cancer activity are urgently needed, and it is our hope that this review will stimulate further research for elucidating and appreciating the value of this nature's wonder agent.

/pdf/emerging-role-of-garcinol-the-antioxidant-chalcone-from-2lse354dcd.pdf

Emerging role of Garcinol, the antioxidant chalcone from Garcinia indica Choisy and its synthetic analogs

A Xanthone from Pericarps of Garcinia mangostana.

Two new prenylated xanthones, subelliptenone H and I, were isolated from the root bark of Garcinia subelliptica. The structures were determined by NMR spectroscopy including 2D techniques and chemical transformation. They both had a 1,1-dimethylallyl group and an isoprenyl group cyclized with the O-function.

Two Xanthones with a 1,1-Dimethylallyl Group in Root Bark of Garcinia subelliptica.

/pdf/antibacterial-activity-of-some-garcinia-benzophenone-22mzc064d6.pdf

Tanaka

Papers

A Xanthone from Pericarps of Garcinia mangostana.

Two Xanthones with a 1,1-Dimethylallyl Group in Root Bark of Garcinia subelliptica.

Antibacterial Activity of Some Garcinia Benzophenone Derivatives against Methicillin-Resistant Staphylococcus aureus.

Antibacterial Activity of Xanthones from Guttiferaeous Plants against Methicillin-resistant Staphylococcus aureus.

Two New Xanthones from the Root Bark of Garcinia subelliptica.