The present invention provides cyclopentane heptanoic acid, 2-cycloalkyl or arylalkyl compounds, which may be substituted in the 1-position with amino, amido, ether or ester groups, e.g., a 1-OH cyclopentane heptanoic acid, 2-(cycloalkyl or arylalkyl) compound. The cyclopentane heptanoic acid, 2-(cycloalkyl or arylalkyl) compounds of the present invention are potent ocular hypotensives, and are particularly suitable for the management of glaucoma. Moreover, the cyclopentane heptanoic, 2-(cycloalkyl or arylalkyl) compounds of this invention are smooth muscle relaxants with broad application in systemic hypertensive and pulmonary diseases; smooth muscle relaxants with application in gastrointestinal disease, reproduction, fertility, incontinence, shock, etc.

Non-acidic cyclopentane heptanoic acid, 2-cycloalkyl or arylalkyl derivatives as therapeutic agents

A single chip protocol converter integrated circuit (IC) capable of receiving packets generating according to a first protocol type and processing said packets to implement protocol conversion and generating converted packets of a second protocol type for output thereof, the process of protocol conversion being performed entirely within the single integrated circuit chip. The single chip protocol converter can be further implemented as a macro core in a system-on-chip (SoC) implementation, wherein the process of protocol conversion is contained within a SoC protocol conversion macro core without requiring the processing resources of a host system. Packet conversion may additionally entail converting packets generated according to a first protocol version level and processing the said packets to implement protocol conversion for generating converted packets according to a second protocol version level, but within the same protocol family type. The single chip protocol converter integrated circuit and SoC protocol conversion macro implementation include multiprocessing capability including processor devices that are configurable to adapt and modify the operating functionality of the chip.

Single chip protocol converter

The present invention relates to certain 1,2,3-trisubstituted aryl and heteroaryl derivatives of Fomula (Ia) that are modulators of metabolism. Accordingly, compounds of the present invention are useful in the prophylaxis or treatment of metabolic disorders and complications thereof, such as, diabetes and obesity.

1,2,3-Trisubstituted aryl and heteroaryl derivatives as modulators of metabolism and the prophylaxis and treatment of disorders related thereto such as diabetes and hyperglycemia

A new type touch sensing device comprises a touch panel with a plurality of transparent touch electrodes, a LC parallel resonant circuit connected to the touch electrode and an oscillation circuit. The LC resonant circuit has a resonant point on a same frequency with the oscillation frequency of the oscillation circuit. The touch/non-touch condition to the touch electrode is detected as a change of voltage value at the connecting point of the LC resonant circuit and touch electrode with an increased ON-OFF ratio.

Touch sensing device

The present invention relates to certain fused aryl and heteroaryl derivatives of Formula (I) that are modulators of metabolism. Accordingly, compounds of the present invention are useful in the prophylaxis or treatment of metabolic disorders and complications thereof, such as, diabetes and obesity.

Fused-aryl and heteroaryl derivatives as modulators of metabolism and the prophylaxis and treatment of disorders related thereto

Novel 5- or 7-monohalogenated or 5,7-dihalogenated 6 -PGI 1 and 5- or 7-monohalogenated or dihalogenated PGI 2 (except 5-monofluorinated PGI 2 ) The novel halogenated prostacyclins are useful for controlling vascular actions and also in organ transplantation, extra-corporeal circulation and the like The present invention also provides processes for preparing the novel halogenated prostacyclins

Halogenated prostacyclins pharmaceutical use thereof and hydroxy intermediates therefore

PURPOSE:To obtain a 2-(4-alkoxy-3-cyanophenyl)thiazole derivative on a large scale, without using a cyano compound, through 4 processes via two new intermediates and with easy purification process by using the starting compoun of 2-(4-hydroxyphenyl)thiazole derivative. CONSTITUTION:A new compound of formula II is obtained by reacting a 2-(4- hydroxyphenyl)thiazole derivative of formula I [X and Y are H, alkyl, COOH, alkoxycarbonyl, carbamoyl or alkyl (mono- or disubstituted) aminocarbonyl] with hexamthylenetetramine in the presence of an organic acid. The obtained product of formula II is made to react with hydroxylamine to obtain a new compound of formula III. The obtained reaction product of formula III is subjected to the reaction with an alkylating agent of the formula R-Z (R is alkyl or aralkyl; Z is halogen, alkylsulfonyloxy or arylsulfonyloxy) to obtain a 2-(4-alkoxy-3-cyanophenyl)thiazole derivative of formula IV. Alternatively, the compound of formul IV is obtained by reacting a compound of formula II with the alkylating agent and successively reacting the obtained compound of formula V with hydroxylamine.

Production of 2-(4-alkoxy-3-cyanophenyl)thiazole derivative and new production intermediate therefor

Novel 5-alkylidene-2-halo-4-substituted-2-cyclopentenone and process for production thereof. The novel 5-alkylidene-2-halo-4-substituted-2-cyclopentenones are represented by the following formula (I): ##STR1## wherein Ra represents a substituted or unsubstituted aliphatic hydrocarbon group having 1 to 12 carbon atoms or a substituted or unsubstituted phenyl group, Rb represents a substituted or unsubstituted aliphatic hydrocarbon group having 1 to 12 carbon atoms, and X represents a halogen atom. The novel cyclopentenones possess excellent pharmaceutical activities including anti-tumor activity, antiviral activity and antimicrobial activity.

5-alkylidene-2-halo-4-substituted-2-cyclopentenone and process for production thereof

PURPOSE:To reduce the power consumption of a display controller itself by changing a clock frequency inside the display controller at the same time when a back light is turned off. CONSTITUTION:A display device is provided with a liquid crystal display 5 with back light, back light control circuit 4 to control the ON/OFF of a back light power source, and display controller 6 to control display on the liquid crystal display 5. Then, the display controller 6 is provided with a display OFF detecting means, clock display part and display data mask means. When a back light OFF signal is received from the back light control circuit 4, the display OFF detecting means instructs clock switching or clock stop to the clock control part, the clock control part controls a clock for display and a clock for memory access and stops a sequence inside the display controller, and the display data mask means forcedly fixes display data.

Power control system for display device

Novel optically active compounds of 4-protected hydroxy-cyclopent-2-en-1-ones of the formula ##STR1## wherein R is a splittable protective group for an alcoholic hydroxyl group, and a process for preparing the 4-protected hydroxycyclopent-2-en-1-ones by oxidizing monohydroxy-protected derivatives of cyclopent-1-ene-3,5-diol expressed by the following formula ##STR2## wherein R is the same as defined above Optically active 4-hydroxycyclopent-2-en-1-one which is an optically active isomer of the compound of formula (2); or optically active cyclopent-1-en-3,5-diol (R-isomer) and a novel diacyl derivative of the diol, a novel monoacylmonosilyl-derivative of the diol and a novel monoacylmonotetrahydropyranol-derivative of the diol, which are intermediates for the protective derivative of formula (1) Processes are also provided for preparing the protective derivatives of formula (1) by converting these intermediates by esterification, hydrolysis, enzymatic processes, etc The optically active compounds of formula (2) are useful as precursors for the preparation of prostaglandin or its analogues

Tanaka Toshio

Papers

Halogenated prostacyclins pharmaceutical use thereof and hydroxy intermediates therefore

Production of 2-(4-alkoxy-3-cyanophenyl)thiazole derivative and new production intermediate therefor

5-alkylidene-2-halo-4-substituted-2-cyclopentenone and process for production thereof

Power control system for display device

Process for the preparation of 4-hydroxycyclopent-2-en-1-one derivatives