Nanotechnology in concrete – A review

Recent genomic studies have resulted in an emerging understanding of the role of chromatin regulators in the development of cancer. EZH2, a histone methyl transferase subunit of a Polycomb repressor complex, is recurrently mutated in several forms of cancer and is highly expressed in numerous others. Notably, both gain-of-function and loss-of-function mutations occur in cancers but are associated with distinct cancer types. Here we review the spectrum of EZH2-associated mutations, discuss the mechanisms underlying EZH2 function, and synthesize a unifying perspective that the promotion of cancer arises from disruption of the role of EZH2 as a master regulator of transcription. We further discuss EZH2 inhibitors that are now showing early signs of promise in clinical trials and also additional strategies to combat roles of EZH2 in cancer.

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Targeting EZH2 in cancer

For the past 30 years, improvements in the survival of patients with osteosarcoma have been mostly incremental. Despite evidence of genomic instability and a high frequency of chromothripsis and kataegis, osteosarcomas carry few recurrent targetable mutations, and trials of targeted agents have been generally disappointing. Bone has a highly specialized immune environment and many immune signalling pathways are important in bone homeostasis. The success of the innate immune stimulant mifamurtide in the adjuvant treatment of non-metastatic osteosarcoma suggests that newer immune-based treatments, such as immune checkpoint inhibitors, may substantially improve disease outcome.

Translational biology of osteosarcoma

Technical and commercial progress in the adoption of geopolymer cement

Clinicopathologic correlates of solitary fibrous tumors.

Based on FEA for three bridge models with varying skew angles, the effect of skew angle on the design moment and shear of skewed bridge structures was studied and also compared to AASHTO specifications. The results show that, generally, ASSHTO-LFD covers FEM in moment distribution factor, but a little less in shear distribution factor, and that, however, AASHTO-LRFD reduces moment distribution factor below AASHTO-LFD and near to FEM, but increases shear distribution factor a lot beyond AASHTO-LFD and FEM.

Tao Ji

Papers

Load Distribution for Moment and Shear on Skewed Bridge Structures