Tatyana V. Taksir

TL;DR: It is demonstrated for the first time that IGF-1 attenuates the pathological activity of non-neuronal cells that contribute to disease progression and attenuates glial cell-mediated release of tumor necrosis factor-alpha (TNF-alpha) and nitric oxide (NO).

TL;DR: This study examines the merits of administering a recombinant adeno-associated viral vector designed to deliver small interfering RNA (siRNA) that targets the degradation of the Htt transcript to lower Htt levels and correct the behavioral, biochemical, and neuropathological deficits shown to be associated with the YAC128 mouse model of HD.

TL;DR: The findings show that the ASMKO brain is responsive to ASM replacement and that retrograde transport of AAV2 functions as a platform for widespread gene delivery and reversal of pathology in affected brain.

TL;DR: It is shown that adeno-associated virus serotype 4 (AAV4)-mediated expression of insulin-like growth factor-1 (IGF-1) or vascular endothelial growth factor (VEGF)-165 in the cellular components of the ventricular system leads to trophic factor delivery throughout the CNS, delayed motor decline and a significant extension of survival in SOD1(G93A) transgenic mice.

TL;DR: Intensive investigation of the major determinants of H+ concentration suggests that acidosis is also due in part to the presence of an unknown anion, which provides insights into the pathogenesis of ALS as well as potential targets for drug development.