T
Tawanda Zininga
Researcher at University of Venda
Publications - 34
Citations - 663
Tawanda Zininga is an academic researcher from University of Venda. The author has contributed to research in topics: Chaperone (protein) & Heat shock protein. The author has an hindex of 12, co-authored 28 publications receiving 434 citations. Previous affiliations of Tawanda Zininga include Stellenbosch University.
Papers
More filters
Journal ArticleDOI
Heat Shock Proteins as Immunomodulants.
TL;DR: The various metabolic pathways in which various Hsps manifest immune modulation are discussed, including their effects on immune cells depends on a number of aspects such as concentration of the respective Hsp species.
Journal ArticleDOI
Plasmodium falciparum Hop (PfHop) Interacts with the Hsp70 Chaperone in a Nucleotide-Dependent Fashion and Exhibits Ligand Selectivity.
Tawanda Zininga,Stanely Makumire,Grace Wairimu Gitau,James M. Njunge,Ofentse Jacob Pooe,Hanna Klimek,Robina Scheurr,Hartmann Raifer,Earl Prinsloo,Jude M. Przyborski,Heinrich C. Hoppe,Addmore Shonhai +11 more
TL;DR: The findings suggest that PfHop serves as a module that brings these two prominent chaperones (PfHsp70-1 and PfHsp90) into a functional complex and is capable of self-association in presence or absence of ATP/ADP.
Journal ArticleDOI
Overexpression, Purification and Characterisation of the Plasmodium falciparum Hsp70-z (PfHsp70-z) Protein.
Tawanda Zininga,Ikechukwu Achilonu,Heinrich C. Hoppe,Earl Prinsloo,Heini W. Dirr,Addmore Shonhai +5 more
TL;DR: Biochemical assays conducted using recombinant PfHsp70-z protein demonstrated that the protein is heat stable and possesses ATPase activity, and it was observed that PfH Sp 70-z is capable of self-association, providing further evidence for its role as a chaperone and possible nucleotide exchange factor of PfHSp70-1.
Journal ArticleDOI
(-)-Epigallocatechin-3-Gallate Inhibits the Chaperone Activity of Plasmodium falciparum Hsp70 Chaperones and Abrogates Their Association with Functional Partners.
Tawanda Zininga,Lebogang Ramatsui,Pertunia Bveledzani Makhado,Stanley Makumire,Ikechukwu Achilinou,Heinrich C. Hoppe,Heini W. Dirr,Addmore Shonhai +7 more
TL;DR: This study constitutes the first direct evidence suggesting that the antiplasmodial activity of EGCG is at least in part accounted for by its inhibition of Hsp70 function.
Journal ArticleDOI
Plasmodium falciparum Hsp70-z, an Hsp110 homologue, exhibits independent chaperone activity and interacts with Hsp70-1 in a nucleotide-dependent fashion
Tawanda Zininga,Ikechukwu Achilonu,Heinrich C. Hoppe,Earl Prinsloo,Heini W. Dirr,Addmore Shonhai +5 more
TL;DR: It is established that PfHsp70-z possesses independent chaperone activity, and appears to be marginally more effective in suppressing protein aggregation than its cytosol-localized partner, PfHSP70-1.