Thanh-Dao Tran

TL;DR: Compounds f5, f6 and t5 are potential candidates for future drug discovery and development and had strong activities against both susceptible and resistant Staphylococcus aureus strains, but not activity against a vancomycin and methicillin resistant StAPHylococci strains isolated from a human sample.

TL;DR: Combinations of chalcones with conventional antibiotics could be an effective alternative in the treatment of infection caused by MRSA.

TL;DR: A series of 2'-hydroxychalcones has been synthesized and screened for their in vitro inhibitory activities of cyclooxygenase-2 catalyzed prostaglandin production from lipopolysaccharide-treated RAW 264.7 cells, and structure-activity relationship study suggested that inhibitory activity against prostaglandsin E(2) production was governed to a greater extent by the substituent on B ring of the chalcone.

TL;DR: Hit compounds for reversing MDR were discovered from the in-house and DrugBank databases through virtual screening using prediction models and molecular docking in an attempt to restore cancer cell sensitivity to cytotoxic drugs.

TL;DR: QSAR analysis, virtual screening and molecular docking were implemented in an effort to discover novel SA NorA efflux pump inhibitors to analyze the binding ability by docking studies on NorA homology model.