“Unpaired Image-to-Image Translation using Cycle-Consistent Adversarial Networks”の学習報告

Biodegradable polymeric nanoparticles as drug delivery devices

Infrared spectroscopy is one of the oldest and well established experimental techniques for the analysis of secondary structure of polypeptides and proteins. It is convenient, non-destructive, requires less sample preparation, and can be used under a wide variety of conditions. This review introduces the recent developments in Fourier transform infrared (FTIR) spectroscopy technique and its applications to protein structural studies. The experimental skills, data analysis, and correlations between the FTIR spectroscopic bands and protein secondary structure components are discussed. The applications of FTIR to the secondary structure analysis, conformational changes, structural dynamics and stability studies of proteins are also discussed.

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Fourier Transform Infrared Spectroscopic Analysis of Protein Secondary Structures

s, and 360 patents, and edited 12 books. He has also received over 80 major awards including the Gairdner Foundation International Award, Lemelson-MIT prize, ACS’s Applied Polymer Science and Polymer Chemistry Awards, AICHE’s Professional Progress, Bioengineering, Walker and Stine Materials Science and Engineering Awards. In 1989, Dr. Langer was elected to the Institute of Medicine of the National Academy of Sciences, and in 1992 he was elected to both the National Academy of Engineering and the National Academy of Sciences. He is the only active member of all three National Academies. Kevin Shakesheff was born in Ashington, Northumberland, U.K., in 1969. He received his Bacheclor of Pharmacy degree from the University of Nottingham in 1991 and a Ph.D. from the same institution in 1995. In 1996 he became a NATO Postdoctoral Fellow at MIT, Department of Chemical Engineering. He is currently an EPSRC Advanced Fellow at the School of Pharmaceutical Sciences, The University of Nottingham. His research group investigates new methods of engineering polymer surfaces and the application of these engineered materials in drug delivery and tissue engineering. 3182 Chemical Reviews, 1999, Vol. 99, No. 11 Uhrich et al.

Polymeric Systems for Controlled Drug Release

In the present Communication, a completely "green" synthetic method for producing silver nanoparticles is introduced. The process is simple, environmentally benign, and quite efficient. By gentle heating of an aqueous starch solution containing silver nitrate and glucose, we produce relatively monodisperse, starched silver nanoparticles. beta-d-Glucose serves as the green reducing agent, while starch serves as the stabilization agent.

Completely "green" synthesis and stabilization of metal nanoparticles.

L'invention concerne des methodes et des compositions permettant de conserver des materiaux bioactifs, tels que des virus, des bacteries, des cellules ou de liposomes, dans des particules lyophilisees adaptees a l'administration pulmonaire. L'invention concerne egalement des methodes consistant a lyophiliser par pulverisation des preparations, de sorte a obtenir des particules lyophilisees stables.

Lyophilisation par pulverisation de compositions a administration pulmonaire

L'invention concerne des methodes de solubilisation et de clivage proteolytique d'agregats de proteines de fusion, telles que des proteines de fusion autocatalytiques, a des pressions superieures a la pression atmospherique afin de produire des polypeptides cible solubles.

Solubilisation de corps d'inclusion haute pression en présence d'une protéase

Embodiments of the present invention provide for novel compositions and methods for making and using a thermally stable broad spectrum human papilloma virus (HPV) vaccine or immunogenic formulation. Certain embodiments concern lyophilizing HPV formulations in the presence or absence of adjuvants. Other embodiments concern lyophilizing HPV capsomere vaccines and other immunogenic agents to increase stability or reduce degradation of HPV peptides to prolong storage, delivery and use. In yet other embodiments, a single immunogenic formulation can include a thermally stable composition of a broad-spectrum HPV immunogenic composition against multiple HPV types. In some embodiments, a stabilizing formulation can include RG1 HPV16VLP antigens in a hypertonic mixture of a disaccharide and a volatile buffer.

Compositions, methods and uses for thermally stable broad-spectrum human papillomavirus formulations

A Single Dose, Thermostable, Trivalent Human Papillomavirus Vaccine Formulated Using Atomic Layer Deposition.

Lyophilized Filovirus Glycoprotein Vaccines: Peroxides in a Vaccine Formulation with Polysorbate 80-containing Adjuvant are Associated with Reduced Neutralizing Antibody Titers in both Mice and Non-human Primates.

Theodore W. Randolph

Papers

Lyophilisation par pulverisation de compositions a administration pulmonaire

Solubilisation de corps d'inclusion haute pression en présence d'une protéase

Compositions, methods and uses for thermally stable broad-spectrum human papillomavirus formulations

A Single Dose, Thermostable, Trivalent Human Papillomavirus Vaccine Formulated Using Atomic Layer Deposition.

Lyophilized Filovirus Glycoprotein Vaccines: Peroxides in a Vaccine Formulation with Polysorbate 80-containing Adjuvant are Associated with Reduced Neutralizing Antibody Titers in both Mice and Non-human Primates.