Theoni K. Georgiou

TL;DR: This review focuses mainly on the studies published over the last 10 years on the synthesis and use of thermoresponsive polymers for biomedical applications including drug delivery, tissue engineering and gene delivery.

TL;DR: The recent literature on chemically cross-linked amphiphilic polymer networks is reviewed in this article, where the main subjects covered are network synthesis, characterization, modeling and applications, and the most important developments of the past year in the field of polymer networks involved mainly new syntheses: Cross-linked stars of various star architectures, crosslinked linear chains of various architectures and compositions.

TL;DR: Four different types of therapies/treatments are examined namely drug delivery, gene delivery, photodynamic therapy and hyperthermia treatment combined with different imaging moieties like magnetic resonance imaging agents, fluorescent agents and microbubbles for ultrasound imaging.

TL;DR: Systematic variation of the amounts of star polymer and plasmid DNA used in the transfections led to an optimization of the performance of this star polymer, yielding overall transfection efficiencies of 15%, comparable to the optimum overallTransfection efficiency of the commercially available transfectION reagent SuperFect of 13%.

TL;DR: All four star copolymers showed decreased toxicity compared to that of the DMAEMA star homopolymer for the same amounts of star polymer tested, while the hydrodynamic diameters in water indicated some aggregation for all the star polymers except for the statistical copolymer star.