T
Thomas C. Vary
Researcher at Pennsylvania State University
Publications - 142
Citations - 8704
Thomas C. Vary is an academic researcher from Pennsylvania State University. The author has contributed to research in topics: Skeletal muscle & Phosphorylation. The author has an hindex of 52, co-authored 142 publications receiving 8312 citations.
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Journal ArticleDOI
Leucine Stimulates Translation Initiation in Skeletal Muscle of Postabsorptive Rats via a Rapamycin-Sensitive Pathway
Joshua C. Anthony,Fumiaki Yoshizawa,Tracy G. Anthony,Thomas C. Vary,Leonard S. Jefferson,Scot R. Kimball +5 more
TL;DR: It is demonstrated for the first time that leucine-dependent stimulation of translation initiation in vivo occurs via a rapamycin-sensitive pathway and is unique among the branched-chain amino acids in its ability to stimulate protein synthesis in skeletal muscle of food-deprived rats.
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Orally Administered Leucine Stimulates Protein Synthesis in Skeletal Muscle of Postabsorptive Rats in Association with Increased eIF4F Formation
TL;DR: It is suggested that leucine stimulates protein synthesis in skeletal muscle by enhancing eIF4F formation independently of increases in serum insulin.
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Disruption of BCATm in Mice Leads to Increased Energy Expenditure Associated with the Activation of a Futile Protein Turnover Cycle
Pengxiang She,Tanya Reid,Sarah K. Bronson,Thomas C. Vary,Andras Hajnal,Christopher J. Lynch,Susan M. Hutson +6 more
TL;DR: Highlights from disrupted BCATm mice suggest that elevated BCAAs and/or loss of BCAA catabolism in peripheral tissues play an important role in regulating insulin sensitivity and energy expenditure.
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TNF-α impairs heart and skeletal muscle protein synthesis by altering translation initiation
TL;DR: Data suggest that TNF-alpha impairs skeletal muscle and heart protein synthesis, at least in part, by decreasing mRNA translational efficiency resulting from an impairment in translation initiation associated with alterations in eIF-4E availability.
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Regulation of muscle protein synthesis during sepsis and inflammation
TL;DR: Understanding the cellular basis of the sepsis-induced decrease in translational activity will contribute to the rational development of therapeutic interventions and thereby minimize the debilitating affects of the atrophic response that impairs patient recovery.