T
Thomas F. Budinger
Researcher at Lawrence Berkeley National Laboratory
Publications - 245
Citations - 11214
Thomas F. Budinger is an academic researcher from Lawrence Berkeley National Laboratory. The author has contributed to research in topics: Positron emission tomography & Emission computed tomography. The author has an hindex of 57, co-authored 245 publications receiving 10931 citations. Previous affiliations of Thomas F. Budinger include University of California, Berkeley & University of California, Davis.
Papers
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Journal ArticleDOI
Regional cerebral metabolic alterations in dementia of the Alzheimer type: positron emission tomography with [18F]fluorodeoxyglucose.
Robert P. Friedland,Thomas F. Budinger,Edward Ganz,Yukio Yano,Chester A. Mathis,Betty Koss,Beth A. Ober,Ronald H. Huesman,Steven E. Derenzo +8 more
TL;DR: Positron emission tomography is a most powerful tool for the noninvasive in vivo assessment of cerebral pathophysiology in dementia and suggests that the metabolic effects of Alzheimer disease are most concentrated in the temporoparietal cortex.
Journal ArticleDOI
Convection-enhanced delivery of AAV vector in parkinsonian monkeys ; in vivo detection of gene expression and restoration of dopaminergic function using pro-drug approach
Krys S. Bankiewicz,Jamie L. Eberling,Jamie L. Eberling,Malgorzata Kohutnicka,William J. Jagust,William J. Jagust,Phillip Pivirotto,John Bringas,Janet Cunningham,Thomas F. Budinger,Judith Harvey-White +10 more
TL;DR: D dopamine production has the potential to restore dopamine production, even late in the disease process, at levels that can be maintained during continued nigrostriatal degeneration, and a fundamental obstacle in the gene therapy approach to the central nervous system can be overcome by using convection-enhanced delivery.
Journal ArticleDOI
Quantitative NMR measurements of hippocampal atrophy in Alzheimer's disease.
J. P. Seab,William J. Jagust,William J. Jagust,S. T. S. Wong,M. S. Roos,Bruce R Reed,Thomas F. Budinger +6 more
TL;DR: The results show that NMR is capable of providing in vivo quantification of diminished hippocampal size in AD which is not cor‐related with overall brain atrophy and which may differentiate AD from normal aging.
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Three-dimensional reconstruction in nuclear medicine emission imaging
TL;DR: In this paper, the authors present application of methods of ascertaining the threedimensional distribution of isotope concentration or density in nuclear medicine, and differ from previous three-dimensional reconstruction efforts of astrophysics, electron microscopy, and X-ray radiology in that statistically poor measurements and photon attenuation are taken into account by the algorithm.
Journal Article
Time-of-Flight Positron Emission Tomography: Status Relative to Conventional PET
TL;DR: At present, due to lack of availability of small and highly efficient, crystal-phototube detectors, TOFPET does not have the high spatial resolution capabilities of non-TOFPET.