T
Thomas J. Stelzner
Researcher at Anschutz Medical Campus
Publications - 22
Citations - 1613
Thomas J. Stelzner is an academic researcher from Anschutz Medical Campus. The author has contributed to research in topics: Pulmonary hypertension & Lung. The author has an hindex of 16, co-authored 22 publications receiving 1593 citations. Previous affiliations of Thomas J. Stelzner include United States Department of Veterans Affairs.
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Journal ArticleDOI
Role of cyclic adenosine monophosphate in the induction of endothelial barrier properties.
TL;DR: Increased endothelial cell cyclic adenine nucleotide activity was an important determinant of endothelial barrier function in vitro, and influences on cytoskeletal assembly may be involved in this process.
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Increased lung endothelin-1 production in rats with idiopathic pulmonary hypertension.
Thomas J. Stelzner,R. F. O'Brien,Masashi Yanagisawa,T. Sakurai,K. Sato,S. Webb,Martin R. Zamora,Ivan F. McMurtry,James H. Fisher +8 more
TL;DR: It is found that there is no increase in lung preproET-1 mRNA or ET-1 levels in adult SDR with an equivalent degree of pulmonary hypertension due to chronic hypoxia, implying that the increases in ET- 1 production in FHR were not a common consequence of all pulmonary hypertensive states.
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Factors influencing the idiopathic development of pulmonary hypertension in the fawn hooded rat.
Kazuhiko Sato,Sally Webb,Alan Tucker,Marlene Rabinovitch,Richard F. O'Brien,Ivan F. McMurtry,Thomas J. Stelzner +6 more
TL;DR: It is found that pulmonary hypertension could be transmitted to backcross and second filial generation offspring arising from selective matings between FHR and control Wistar Kyoto rats, confirming the heritable basis for pulmonary hypertension in the FHR.
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BQ123, an ETA Receptor Antagonist, Inhibits Endothelin-1-mediated Proliferation of Human Pulmonary Artery Smooth Muscle Cells
TL;DR: The results suggest that ET-1 is a potent co-mitogen for human proximal pulmonary artery SMC and that this effect is transduced by selective activation of the ETA receptor.
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BQ123, an ETA-receptor antagonist, attenuates hypoxic pulmonary hypertension in rats.
S. T. Bonvallet,Martin R. Zamora,K. Hasunuma,K. Sato,N. Hanasato,D. Anderson,Thomas J. Stelzner +6 more
TL;DR: It is concluded that the ETA-receptor antagonist BQ123 attenuates the development of hypoxic pulmonary hypertension in rats in vivo, thereby suggesting a possible contributing role for ET-1 and the Eta receptor in the pathogenesis of this process.