T
Thomas Kocher
Researcher at Paracelsus Private Medical University of Salzburg
Publications - 25
Citations - 665
Thomas Kocher is an academic researcher from Paracelsus Private Medical University of Salzburg. The author has contributed to research in topics: RNA & Gene. The author has an hindex of 14, co-authored 25 publications receiving 484 citations. Previous affiliations of Thomas Kocher include University of Salzburg.
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Journal ArticleDOI
Development of CLL in the TCL1 transgenic mouse model is associated with severe skewing of the T-cell compartment homologous to human CLL
J. Piñón Hofbauer,Christoph Heyder,Ursula Denk,Thomas Kocher,Claudia Holler,D. Trapin,Daniela Asslaber,Inge Tinhofer,Richard Greil,Alexander Egle +9 more
TL;DR: The TCL1 transgenic mouse model is validated for analysis of T-cell phenotypes and a CLL-dependent antigen-driven skewing of T cells in these mice is suggested, suggesting that antigen-dependent differentiation toward the T memory pool is initiated by murine CLL cells.
Journal ArticleDOI
COL7A1 Editing via CRISPR/Cas9 in Recessive Dystrophic Epidermolysis Bullosa
Stefan Hainzl,Patricia Peking,Thomas Kocher,Eva M. Murauer,Fernando Larcher,Marcela Del Rio,Blanca Duarte,Markus Steiner,Alfred Klausegger,Johann W. Bauer,Julia Reichelt,Ulrich Koller +11 more
TL;DR: An ex vivo CRISPR/Cas9-mediated homology-directed repair approach is exploited for the correction of a frequent inherited mutation in exon 80 of COL7A1, causing the severe blistering skin disease recessive dystrophic epidermolysis bullosa.
Journal ArticleDOI
Cut and Paste: Efficient Homology-Directed Repair of a Dominant Negative KRT14 Mutation via CRISPR/Cas9 Nickases.
Thomas Kocher,Patricia Peking,Alfred Klausegger,Eva M. Murauer,Josefina Piñón Hofbauer,Verena Wally,Thomas Lettner,Stefan Hainzl,Michael Ablinger,Johann W. Bauer,Julia Reichelt,Ulrich Koller +11 more
TL;DR: A highly efficient and specific gene-editing approach for KRT14 is demonstrated, offering a causal treatment option for EBS, and a promising safety profile for the CRISPR/Cas9 double-nicking approach is achieved.
Journal ArticleDOI
A Gene Gun-mediated Nonviral RNA trans-splicing Strategy for Col7a1 Repair.
Patricia Peking,Ulrich Koller,Stefan Hainzl,Sophie Kitzmueller,Thomas Kocher,Elisabeth Mayr,Alexander Nyström,Thomas Lener,Julia Reichelt,Johann W. Bauer,Eva M. Murauer +10 more
TL;DR: A novel in vivo nonviral RNA therapy approach to restore type VII collagen expression for causative treatment of dystrophic epidermolysis bullosa is described.
Journal ArticleDOI
Improved Double-Nicking Strategies for COL7A1-Editing by Homologous Recombination
Thomas Kocher,Roland N. Wagner,Alfred Klausegger,Christina Guttmann-Gruber,Stefan Hainzl,Johann W. Bauer,Julia Reichelt,Ulrich Koller +7 more
TL;DR: This work provides a framework for efficient, precise, and safe repair of COL7A1, which lies at the heart of a future curative therapy of RDEB.