T
Thomas P. Kennedy
Researcher at Tulane University
Publications - 123
Citations - 5841
Thomas P. Kennedy is an academic researcher from Tulane University. The author has contributed to research in topics: Heparin & Lung injury. The author has an hindex of 37, co-authored 123 publications receiving 5541 citations. Previous affiliations of Thomas P. Kennedy include Georgia Regents University & Duke University.
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Journal ArticleDOI
Prevention of Contrast-Induced Nephropathy With Sodium Bicarbonate: A Randomized Controlled Trial
Gregory J. Merten,W. Patrick Burgess,Lee V. Gray,Jeremiah H. Holleman,Timothy S. Roush,Glen J. Kowalchuk,Robert M. Bersin,Arl Van Moore,Charles A. Simonton,Robert A. Rittase,H. James Norton,Thomas P. Kennedy +11 more
TL;DR: Hydration with sodium bicarbonate before contrast exposure is more effective than hydration with Sodium chloride for prophylaxis of contrast-induced renal failure.
Journal ArticleDOI
Transforming growth factor-β1 induces Nox4 NAD(P)H oxidase and reactive oxygen species-dependent proliferation in human pulmonary artery smooth muscle cells
Anne Sturrock,Barbara C. Cahill,Kimberly Norman,Thomas P. Huecksteadt,Kenneth E. Hill,Karl Sanders,Shreekanth V. Karwande,James C. Stringham,David A. Bull,Martin Gleich,Thomas P. Kennedy,John R. Hoidal +11 more
TL;DR: The consequences of TGF-β1 stimulation in pulmonary hypertension are studied to assess its effect on the pulmonary circulation and provide clues about its role in disease progression.
Journal ArticleDOI
NOX5 NAD(P)H oxidase regulates growth and apoptosis in DU 145 prostate cancer cells.
Sukhdev S. Brar,Zachary Corbin,Thomas P. Kennedy,Richelle Hemendinger,Lisa R. Thornton,Bettina Bommarius,Rebecca S. Arnold,A. Richard Whorton,Anne Sturrock,Thomas P. Huecksteadt,Mark T. Quinn,Kevin Krenitsky,Kristia G. Ardie,J. David Lambeth,John R. Hoidal +14 more
TL;DR: Results indicate that ROS generated by the newly described NOX5 oxidase are essential for prostate cancer growth, possibly by providing trophic intracellular oxidant tone that retards programmed cell death.
Journal ArticleDOI
Role of reactive oxygen species in reperfusion injury of the rabbit lung.
Thomas P. Kennedy,N. V. Rao,Christopher M. Hopkins,Larry Pennington,Elizabeth A. Tolley,John R. Hoidal +5 more
TL;DR: A model of reperfusion injury in Krebs buffer-perfused rabbit lungs, characterized by pulmonary vasoconstriction, microvascular injury, and marked lung edema formation is developed, offering potential strategies for improved organ preservation and treatment of reperFusion injury after pulmonary thromboembolectomy.
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An NAD(P)H oxidase regulates growth and transcription in melanoma cells.
Sukhdev S. Brar,Thomas P. Kennedy,Anne Sturrock,Thomas P. Huecksteadt,Mark T. Quinn,A. Richard Whorton,John R. Hoidal +6 more
TL;DR: Melanoma proliferation was reduced by NAD(P)H oxidase inhibitors and by transfection of antisense but not sense oligonucleotides for p22(phox) and NOX4, which suggests that ROS generated in autocrine fashion by an NAD(H) oxidase may play a role in signaling malignant melanoma growth.