Showing papers by "Tilman B. Drüeke published in 1980"
70 citations
TL;DR: The hypothesis that circulating immune complexes involving HBsAg may be involved in the pathogenesis of periarteritis nodosa is supported.
47 citations
Journal Article•
TL;DR: It was concluded that parathyroid glands of the rat could be successfully autografted after previous freezing using a simplified cryopreservation technique and the results obtained were comparable with, even though not as perfect as, that observed after immediate autotransplantation.
6 citations
TL;DR: An acute, inhibitory effect of PTH on intestinal absorption of sodium, calcium, and water in normal as well as acutely thyroparathyroidectomized rats is reported.
Abstract: PTH decreases phosphate reabsorption in the proximal renal tubule and also at more distal tubular sites (1). In contrast to this in vivo effect, PTH has been reported to increase cellular uptake of 32P04 in vitro in a number of tissues including intestine (2) and kidney (3,4), possibly by stimulating an active, energy-dependent “phosphate-pump” (5). This apparent discrepancy between observations made in vivo and in vitro is not well understood at present. In the intestine, PTH stimulates phosphate absorption indirectly via an increased formation of 1,25 (OH)2 vitamin D3 (6). A direct effect of PTH on intestinal transport remains controversial. We have previously reported an acute, inhibitory effect of PTH on intestinal absorption of sodium, calcium, and water in normal (7) as well as acutely thyroparathyroidectomized (8) rats.
2 citations
Journal Article•
TL;DR: It is concluded that the hyperparathyroid state is accompanied by a decrease of RBC production in the rat, and it is probable that a similar pathogenesis underlies the anemia of patients with primary or secondary hyper parathyroidism.
Abstract: Red blood cell (RBC) production has been explored in hyperparathyroid as compared to normal rats. The hyperparathyroid state was obtained by feeding the rats a calcium-deficient diet during 30 days. A significant decrease (p less than 0.001) in reticulocyte count and in erythrocyte 59Fe incorporation was observed in hyperparathyroid rats when compared to control animals. A comparable inhibition of erythrocyte 59Fe incorporation in hyperparathyroid rats was found when the study was performed after stimulating bone marrow activity by acute arterial hemorrhage. These results of decreased RBC production using a model of endogenous hyperparathyroidism could be confirmed in additional experiments using a model of exogenous hyperparathyroidism. In this model, the rats received either parathyroid extract (3 x 10 USP/day during 8 days) or vehicle only. Again, a decrease in erythrocyte 59Fe incorporation was observed in hyperparathyroid animals when compared to control animals. It is concluded that the hyperparathyroid state is accompanied by a decrease of RBC production in the rat. It is probable that a similar pathogenesis underlies the anemia of patients with primary or secondary hyperparathyroidism.
1 citations