Tim Cernak

TL;DR: This review details a toolbox of intermolecular C-H functionalization chemistries with proven applicability to drug-like molecules, classified by regioselectivity patterns, and gives guidance on how to systematically develop LSF strategies using these patterns and other considerations.

TL;DR: This Review focuses on so-called magic methyl effects on binding potency, where the seemingly mundane change of C�H to CMe improves the IC50 value of a drug candidate more than 100-fold.

TL;DR: An automated dosing and characterization protocol for optimizing chemical reaction conditions on the microgram scale is presented, which allowed them to screen numerous base and ligand combinations for catalytic C-N bond-forming reactions between complex pairs of compounds, in short supply, that resisted standard coupling conditions.

TL;DR: A standardized complex molecule diagnostic approach using collections of relevant drug-like molecules which are called chemistry informer libraries are reported.

TL;DR: In this paper, aufsatzes bildet der so genannte magische Methyleffekt auf das Bindungsvermogen, bei dem der scheinbar banale Wechsel von der C-H- zur C-Me-Gruppe den IC50-Wert eines potenziellen Wirkstoffs um mehr als das 100fache verbessert.