Tiziana Mangieri

TL;DR: Euthyroid pregnant women who are positive for TPOAb develop impaired thyroid function, which is associated with an increased risk of miscarriage and premature deliveries, and Substitutive treatment with LT(4) is able to lower the chance of miscarriages and premature delivery.

TL;DR: The increased incidence of pregnancy loss in pregnant women with TSH levels between 2.5 and 5.0 mIU/liter provides strong physiological evidence to support redefining the TSH upper limit of normal in the first trimester to 2.

TL;DR: Treatment of hypothyroidism or hyperthyroidism identified by screening a low-risk group was associated with a lower rate of adverse outcomes and universal screening compared with case finding did not result in a decrease in adverse outcomes.

TL;DR: Selenium supplementation during pregnancy and in the postpartum period reduced thyroid inflammatory activity and the incidence of hypothyroidism.

TL;DR: The pregnancy rate is not affected either by presence of TPOAb or treatment with LT4, however, T POAb (+) women show a poorer delivery rate compared to TPO Ab (-) and LT4 treatment in TPO ab (+) does not affect the delivery rate.