Tomas B. Walden

TL;DR: It is reported here that chronic treatment with the peroxisome proliferator-activated receptor γ agonist rosiglitazone promotes not only the expression of PGC-1α and mitochondriogenesis in these cells but also a norepinephrine-augmentable UCP1 gene expression in a significant subset of the cells, providing these cells with a genuine thermogenic capacity.

TL;DR: The interlinkage between the myocyte and the brown preadipocyte confirms the distinct origin for brown versus white adipose tissue and also represents a plausible explanation as to why brown adipocytes ultimately specialize in lipid catabolism rather than storage, much like oxidative skeletal muscle tissue.

TL;DR: The effect of physiologically induced recruitment of thermogenic function (cold acclimation) on the expression pattern of the genes was quantified; in general, the depot pattern dominated over the recruitment effects.

TL;DR: In this paper, the miRNAs are differentially expressed in white and brown primary cell cultures for differential expression of microRNAs, showing that brown and myocytes derive from a common cell lineage that specifies energy-dissipating cells.

TL;DR: Regulation of the PINK1 locus, previously linked to neurodegen‐erative disease, is altered in obesity, type 2 diabetes and inactivity, while the combination of RNAi experiments and clinical data suggests a role for Pink1 in cell energetics rather than in mitochondrial biogenesis.