Tomas Majtan

TL;DR: A hydrogen sulfide selective fluorogenic probe, 7-azido-4-methylcoumarin (AzMC), serves as a highly sensitive assay for cystathionine β-synthase activity, and is suitable for the high-throughput discovery of novel enzyme inhibitors.

TL;DR: The effect of honey and its major royal jelly protein 1 on cytokine and MMP‐9 mRNA transcripts in human keratinocytes is studied.

TL;DR: Among the small-molecule CBS inhibitors, the review highlights the specificity and selectivity problems related to many of the commonly used “CBS inhibitors” and provides a comprehensive review of their pharmacological actions under physiological conditions and in various disease models.

TL;DR: The absence of large conformational changes and the crystal structure of the partially activated pathogenic D444N mutant suggest that the rotation of CBS motifs and relaxation of loops delineating the entrance to the catalytic site represent the most likely molecular mechanism of CBS activation by S-adenosyl-l-methionine.

TL;DR: The crystal structure of an engineered human CBS construct bound to S-adenosylmethionine (AdoMet) reveals the unique binding site of the allosteric activator and the architecture of the human CBS enzyme in its activated conformation, paving the way for the rational design of compounds modulating hCBS activity and thus transsulfuration, redox status, and H2S biogenesis.