Showing papers by "Tomasz Brzostek published in 1988"
Journal Article•
TL;DR: While verapamil decreased statistically significantly pulmonary artery pressures and resistances, it did not deteriorate right ventricular systolic function, although it lowered its stiffness significantly.
Abstract: The study was designed to elucidate verapamil action on the pulmonary vascular bed and right ventricular function and to compare it with the effect of oxygen in view of the fact that calcium antagonists can attenuate hypoxic pulmonary vasoconstriction. 16 patients with secondary, and 4 with primary, pulmonary hypertension and with a mean pulmonary artery systolic pressure of 68.6 +/- 28.7 mmHg were examined. After determination of initial haemodynamic values, the oxygen test (OT) was performed; later on, when the values returned to the initial ones, verapamil was infused into pulmonary artery. Measurements were carried out in the 10th min of OT and until the 30th min after verapamil. While verapamil decreased statistically significantly pulmonary artery pressures and resistances, it did not deteriorate right ventricular systolic function, although it lowered its stiffness significantly. The effect of oxygen was comparable with that of verapamil though the magnitude of changes was smaller.
1 citations
TL;DR: Captopril lowered pulmonary pressures and resistances and no deterioration in right ventricular function was observed, and the response of the pulmonary circulation to captopril 75 mg has been examined in patients with pulmonary hypertension secondary to mitral stenosis.
Abstract: The response of the pulmonary circulation to captopril 75 mg has been examined in 21 patients with pulmonary hypertension secondary to mitral stenosis. The effects of captopril were measured every 15 min up to 2 h by recording pressures in the pulmonary and systemic circulations and by measuring cardiac output.