Tomasz Kosmalski

TL;DR: A review of metal-based cancer drug candidates can be found in this paper, where the benefits and drawbacks regarding the activity and toxicity of the metalbased cancer drugs candidates are discussed.

TL;DR: In this article, transfer hydrogenation of representative aryl and heteroaryl dialkylaminomethyl ketones with formic acid-triethylamine, catalyzed by RuCl[(R,R)-TsDPEN]-η-p-cymene, produces the corresponding β-dialkylamino alcohols, 97-99% ee, in 50-73% yields.

TL;DR: This study is the first to evaluate safety and efficacy of the topical use of statins in patients presenting with nonsegmental vitiligo (NSV), and it is shown that statins act through several immunological pathways, potentially reversing undesirable phenomena underlying autoimmune Vitiligo pathogenesis.

TL;DR: The synthesis of 2-(allylamino)thiazol-4(5H)-one derivatives by the reaction of N-allylthiourea with appropriate α-bromoesters is presented, which appears to be promising and should be subjected to further testing.

TL;DR: The most active compound only in the slight degree inhibits 11β-HSD2 activity and is a selective inhibitor of 11 β-hydroxysteroid dehydrogenase type 1, which can have a real effect on the regulation of the cortisol level in the body.