Tomasz Schneider

TL;DR: Interestingly, all behavioral aberrations described in this paper appear before puberty, which could distinguish the VPA rat model of autism from other animal models of neurodevelopmental disorders, especially rodent models of schizophrenia.

TL;DR: Results confirm existence of similarities between the observed pattern of aberrations in VPA rats and features of disturbed behavior and immune function in autistic patients, and suggest that they are gender-specific, which is intriguing in light of disproportion in boys to girls ratio in autism.

TL;DR: The results suggest that postnatal environmental manipulations can counteract the behavioral alterations in VPA rats, and propose environmental enrichment as an important tool for the treatment of autism spectrum disorders.

TL;DR: The results indicate that estrous cycle-dependent marble-burying behavior displayed by a subgroup of female rats might be a manifestation of ovarian hormone-dependent irritability, and may be used to elucidate the neuroendocrine mechanisms triggering premenstrual irritability and the detailed mode of action of antidepressants when used for PMDD.

TL;DR: A common neurobiological background for the estrous cycle-dependent aggression and depressive-like traits in rodents is suggested, which could potentially aid the elucidation of premenstrual emotional dysfunctions and might be used as an ethological model to study a biochemical and genetic proneness to depression.