Toshihiro Hama

TL;DR: Results suggest that paclitaxel treatment increases TRPV1 expression in DRG neurons and may contribute to functional peripheral neuropathic pain.

TL;DR: A multicenter field survey of environmental contamination and exposure of healthcare professionals to anticancer drugs were performed and CP was detected in 90 samples obtained from 23 subjects, indicating the amount of exposure was greatly different among the facilities.

TL;DR: Investigation of the effects of paclitaxel on the voltage-dependent calcium channel (VDCC) current in rat dorsal root ganglion (DRG) neurons using the whole-cell patch clamp technique found that pac litaxel treatment increases the VDCC current in small- and medium-diameter DRG neurons and upregulates Ca(v)α₂δ-1.

TL;DR: When and how often PN occurs in association with paclitaxel plus carboplatin (PC therapy), a regimen used to treat non-small cell lung cancer, and factors that exacerbate this condition are determined.

TL;DR: Development of irAEs was associated with survival outcome of pembrolizumab treatment in patients with advanced urothelial cancer, and risk factors for exacerbation ofirAEs were positively associated with lymphocyte count at baseline (>2,000/µL).