Showing papers by "Toshiyuki Yamamoto published in 1985"

Treatment of viral warts with pressure-sensitive adhesive tape containing bleomycin sulfate.

Abstract: To the Editor.— The currently employed manipulations for the treatment of common and plantar warts depend mainly on physical and chemical destruction of the warts. 1,2 One of the disadvantages in these maneuvers is associated pain at the treated site. Herein, we report the usefulness of pressure-sensitive adhesive tape containing bleomycin sulfate for common and plantar warts. Acrylic adhesive was casted on a nonwoven fabric laminated polyurethane film as a backing. The adhesive surface of the tape was coated evenly with a solution containing bleomycin sulfate (5.3 mg/mL in ethanol and water [9:1]) and dried at room temperature. The final content of bleomycin sulfate was 60 μg/sq cm of the tape, as assessed by high-performance liquid chromatography. Placebo tape did not contain bleomycin sulfate. Seven patients with common warts and two with plantar warts were selected to participate in our study. They had not been treated previously for warts. Bleomycin

Enzyme-containing plaster

Abstract: PURPOSE: To provide a plaster containing a keratolytic enzyme in a drug- containing layer or a part closer to the skin than the drug-containing layer. CONSTITUTION: A keratolytic enzyme (e.g. protease such as trypsin, pepsin, papain, esterase, bacterium-originated protease, etc.) is added to a drug- containing layer of a plaster or to a part closer to the skin than the drug- containing layer. The amount of the enzyme is 1/1,000W50IU(mg), preferably 1/100W10IU(mg) per 1cm 2 . The plaster produced by the above process is effective to promote the absorption of the drug into the body and to develop the pharma ceutical effect. It is preferable to add a part of the substrate and a coenzyme, etc., to the enzyme to improve the activity. Preferably, the plaster is added with a pH-modifier to improve the enzymatic activity. EFFECT: Enzyme is hardly absorbable in the body and the drug action can be controlled freely to a desired state such as rapid-acting action, durable action, etc. COPYRIGHT: (C)1986,JPO&Japio

Fat-soluble vitamin-containing preparation for retal administration

Abstract: PURPOSE: The titled preparation easily absorbable from the rectum, obtained by blending a fat-soluble vitamin, especially vitamin K with an additive for producing preparation for retal administration. CONSTITUTION: A fat-soluble vitamin (e.g., vitamin A, D, E, F, K, etc.) is blended with an additive for producing preparation of rectal administration, to give a fat-soluble vitamin-containing preparation for rectal administration. Since deficiency of vitamin K is serious to a baby, this preparation which is administered easily orally or by injection and can attain extremely high absorption is preferable. The amount of the fat-soluble vitamin added is preferably 0.1W5wt%. Improved retal absorption can be attained by blending the preparation with an absorption promoting auxiliary, surface active agent, etc. COPYRIGHT: (C)1986,JPO&Japio