T
Tsutomu Shinohara
Researcher at University of Tokushima
Publications - 79
Citations - 604
Tsutomu Shinohara is an academic researcher from University of Tokushima. The author has contributed to research in topics: Medicine & Lung cancer. The author has an hindex of 11, co-authored 61 publications receiving 519 citations.
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Journal ArticleDOI
Serum levels of interleukin 6 in patients with lung cancer.
Hiroaki Yanagawa,Saburo Sone,Y Takahashi,Takashi Haku,Seiji Yano,Tsutomu Shinohara,Takeshi Ogura +6 more
TL;DR: The results suggest that IL-6 may be a mediator of various reactions including an inflammatory response in lung cancer patients and in patients with benign lung diseases.
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Enhanced efficiency by centrifugal manipulation of adenovirus-mediated interleukin 12 gene transduction into human monocyte-derived dendritic cells.
TL;DR: It is reported that the efficiency of in vitro adenovirus-mediated gene transduction into human monocyte-derived DCs can be dramatically enhanced by centrifugation and IL-12 gene-modified human DCs may be therapeutically useful as a good adjuvant in DC-based immunotherapy.
Journal Article
Model of malignant pleural effusion of human lung adenocarcinoma in SCID mice
Seiji Yano,Hiroshi Nokihara,Masaki Hanibuchi,Prahlad Parajuli,Tsutomu Shinohara,Tetsuya Kawano,Saburo Sone +6 more
TL;DR: A model of malignant PE of human adenocarcinoma cells, PC-14, in SCID mice is established and changes of adhesion molecules seem to be one of possible mechanisms involved in higher metastatic potential of PC- 14-PM4 cells.
Journal Article
Nuclear factor-kappaB-dependent expression of metastasis suppressor KAI1/CD82 gene in lung cancer cell lines expressing mutant p53.
Tsutomu Shinohara,Toyokazu Miki,Naoki Nishimura,Hiroshi Nokihara,Hirofumi Hamada,Naofumi Mukaida,Saburo Sone +6 more
TL;DR: It is demonstrated that expression of KAI1/CD82 in PC-14 cells expressing mutant p53 could be augmented by TNF-alpha, and that transfer of the gene for a specific inhibitor of NF-kappaB, IkappaB alphaSR, into PC- 14 cells could inhibit this augmentation.
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Goodpasture's disease in a patient with advanced lung cancer treated with nivolumab: An autopsy case report.
TL;DR: This case provides a possible link between nivolumab and lethal Goodpasture's disease and an autopsy showed crescentic glomerulonephritis and massive alveolar hemorrhage which were compatible with Goodpastures disease.