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Umender Sharma
Researcher at AstraZeneca
Publications - 25
Citations - 913
Umender Sharma is an academic researcher from AstraZeneca. The author has contributed to research in topics: Mycobacterium tuberculosis & RNA polymerase. The author has an hindex of 16, co-authored 24 publications receiving 810 citations. Previous affiliations of Umender Sharma include Indian Institute of Science.
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Journal ArticleDOI
Transcriptional switching in Escherichia coli during stress and starvation by modulation of σ70 activity
TL;DR: There is a case for evolving a unified model of RNAP redistribution during starvation by modulation of sigma(70) activity in E. coli by analysing mechanisms of (p)ppGpp, DksA, 6S RNA and Rsd in a collective manner.
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Efflux Pumps of Mycobacterium tuberculosis Play a Significant Role in Antituberculosis Activity of Potential Drug Candidates
Meenakshi Balganesh,Neela Dinesh,Sreevalli Sharma,Sanjana Kuruppath,Anju V. Nair,Umender Sharma +5 more
TL;DR: It is shown that these four efflux pump KO mutants of M. tuberculosis play a vital role in mediating efflux of different chemical scaffolds and inhibitors of one or several of these efflux pumps could have a significant impact in the treatment of tuberculosis.
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Rv1218c, an ABC Transporter of Mycobacterium tuberculosis with Implications in Drug Discovery
Meenakshi Balganesh,Sanjana Kuruppath,Nimi Marcel,Sreevalli Sharma,Anju V. Nair,Umender Sharma +5 more
TL;DR: Most of the compound classes had significantly better bactericidal activity in the ΔRv 1218c mutant than in the wild-type H37Rv, suggesting the involvement of Rv1218c gene product in effluxing these compounds from M. tuberculosis.
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Antibiofilm Activity and Synergistic Inhibition of Staphylococcus aureus Biofilms by Bactericidal Protein P128 in Combination with Antibiotics.
Sandhya Nair,Srividya Narayanamurthy Desai,Nethravathi Poonacha,Aradhana Vipra,Umender Sharma +4 more
TL;DR: In an in vitro mixed-biofilm model mimicking the wound infection environment, P128 was able to prevent biofilm formation by virtue of its anti-Staphylococcus activity and is an encouraging sign for the development of P128 for treatment of complicated S. aureus infections involving biofilms.
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Phage-derived lysins as potential agents for eradicating biofilms and persisters.
TL;DR: The fact that lysins have shown better efficacy than conventional drugs in animal models of endocarditis and other infections involving biofilms suggests that the lysin can potentially be developed against difficult-to-treat bacterial infections.