U
Un Hye Kwon
Researcher at Yonsei University
Publications - 7
Citations - 324
Un Hye Kwon is an academic researcher from Yonsei University. The author has contributed to research in topics: Osteocalcin & Bone morphogenetic protein 2. The author has an hindex of 6, co-authored 7 publications receiving 294 citations.
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Journal ArticleDOI
Bone Morphogenetic Protein-2 Facilitates Expression of Chondrogenic, not Osteogenic, Phenotype of Human Intervertebral Disc Cells
Dong Jun Kim,Seong Hwan Moon,Hyang Kim,Un Hye Kwon,Moon Soo Park,Keong Jin Han,Soo Bong Hahn,Hwan Mo Lee +7 more
TL;DR: The possibility of rhBMP-2 can be anabolic agent for regenerating matrix of intervertebral disc is raised, as it clearly up-regulated mRNA expression of chondrogenic components and also stimulated proteoglycan synthesis without expression of osteogenic phenotype.
Journal ArticleDOI
Inflammatory cytokines induce fibrosis and ossification of human ligamentum flavum cells.
Jin Oh Park,Byung Ho Lee,Young Mi Kang,Tae Hwan Kim,Ji Young Yoon,Hyang Kim,Un Hye Kwon,Kwang-Il Lee,Hwan Mo Lee,Seong Hwan Moon +9 more
TL;DR: Inflammatory cytokines (IL-6, TNF-&agr;, PGE2, and NO) seem to play a crucial role in hypertrophy and ossification of LF.
Journal ArticleDOI
Tissue engineering of the intervertebral disc with cultured nucleus pulposus cells using atelocollagen scaffold and growth factors.
Kwang-Il Lee,Seong Hwan Moon,Hyang Kim,Un Hye Kwon,Ho Joong Kim,Si-Nae Park,Hwal Suh,Hwan Mo Lee,Hak Sun Kim,Heoung Jae Chun,Il Keun Kwon,Ju Woong Jang +11 more
TL;DR: NP cells in atelocollagens under the stimulation of TGF-&bgr;1 and BMP-2 exhibited anabolic responses in transcriptional and translational levels, suggesting that such an approach can provide a suitable engineered tissue for IVD regeneration with potential for robust refurbishment of matrix.
Journal ArticleDOI
Biologic modification of ligamentum flavum cells by marker gene transfer and recombinant human bone morphogenetic protein-2.
TL;DR: In human LF cells, BMP-2 was found to markedly up-regulate the expression of osteogenic phenotypes and to induce bone nodule formation, and the notion that biologically modified LF cells treated with B MP-2, or with adenovirus-mediated cDNA gene transfer, may facilitate spinal fusion is supported.
Journal ArticleDOI
Pulsed electromagnetic field stimulates cellular proliferation in human intervertebral disc cells.
Hwan Mo Lee,Un Hye Kwon,Hyang Kim,Ho Joong Kim,Boram Kim,Jin Oh Park,Eun Soo Moon,Seong Hwan Moon +7 more
TL;DR: In this paper, the authors investigated the mechanism of cellular proliferation of electromagnetic field (EMF) on human intervertebral disc (IVD) cells, and found that the proliferation of EMF on IVD cells is correlated with the number of intervein connections.