The effects of different doses of potassium iodate (KIO3) on the malignancy of thyroid cancer were investigated. Results showed that the proliferation, migration, and invasion of SW579 thyroid cancer cells were improved by 10-6 M KIO3, which was associated with microRNA(miR)-146a deficit; 10-2 M KIO3 significantly enhanced miR-146a level and suppressed SW579 cell proliferation, migration, and invasion. The diverse effects of KIO3 on SW579 cells were associated with the expression changes in miR-146a targets, Bcl-2, Bax, and caspase-3. Our study concludes that different doses of KIO3 have counteracting effects on the malignancy of thyroid cancer through modulating miR-146a level.

Potassium Iodate Differently Regulates the Proliferation, Migration, and Invasion of Human Thyroid Cancer Cells via Modulating miR-146a.

F. B. OBERHAUSER et al.
1 have recently published results of experiments in which they tried to influence the growth of a rat sarcoma by oral treatment of the animals with solutions of potassium iodate in potassium iodide.

Tumour-inhibiting properties of potassium iodide solution containing potassium iodate.

Beitrag zum Studium der an gesunden und an Krebs erkrankten Ratten angewandten Jodid-Jodat-Mischung

Posttetanic potentiation of monosynaptic reflexes has been used as a paradigm for neuronal plasticity. The explanation for this phenomenon is an increased responsiveness of the synaptic junctions. This would basically required chemical changes of the nervous structures involved. The ventral horn area of the spinal cord was therefore analyzed neurochemically. The determination of the phospholipids revealed an alteration of their composition. Sphingomyelin, phosphatidylcholine and phosphatidylinositide/serine behaved differently, whereas phosphatidylethanolamine and the total phospholipid content remained unchanged.

Neurochemical changes in the cat's spinal cord due to orthodromic tetanic stimuli. I: phospholipids.

As one of us (F. B. O.) had observed that the administration of a mixture of aqueous solutions of potassium iodide and potassium iodate induced favourable effects in cancer patients, we decided to carry out an experimental study in rats.

V. M. Silva

Papers

Anti-tumorigenic action of iodinated compounds.