V
Vadim N. Gladyshev
Researcher at Brigham and Women's Hospital
Publications - 526
Citations - 40499
Vadim N. Gladyshev is an academic researcher from Brigham and Women's Hospital. The author has contributed to research in topics: Selenoprotein & Selenocysteine. The author has an hindex of 102, co-authored 490 publications receiving 34148 citations. Previous affiliations of Vadim N. Gladyshev include Pompeu Fabra University & Howard Hughes Medical Institute.
Papers
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Journal ArticleDOI
Thioredoxin and peptide methionine sulfoxide reductase: convergence of similar structure and function in distinct structural folds.
TL;DR: It is shown that the structures of Trx and PMSR exhibit resemblance in their αβ core regions and that the active site cysteines in two proteins occupy equivalent positions downstream of a central β‐strand and at the N‐terminus of an α‐helix, pointing to a general strategy of identifying new redox regulatory proteins.
Journal ArticleDOI
The Insertion Green Monster (iGM) Method for Expression of Multiple Exogenous Genes in Yeast
Vyacheslav M. Labunskyy,Yo Suzuki,Timothy J. Hanly,Ayako Murao,Frederick P. Roth,Frederick P. Roth,Vadim N. Gladyshev +6 more
TL;DR: The “insertion Green Monster” (iGM) set of expression vectors are described that enable precise insertion of many heterologous genes into the yeast genome in a rapid and reproducible manner and permit simultaneous replacement of selected yeast genes.
Journal ArticleDOI
Structural and biochemical analysis of mammalian methionine sulfoxide reductase B2.
Finn Lillelund Aachmann,Geun-Hee Kwak,Rebecca Del Conte,Hwa-Young Kim,Vadim N. Gladyshev,Alexander Dikiy +5 more
TL;DR: The solution structure of reduced Mus musculus MsrB2 is reported using high resolution nuclear magnetic resonance (NMR) spectroscopy and structural and biochemical analysis supports the catalytic mechanism of MsRB2 that, in contrast to Msrb1, does not involve a resolving cysteine (Cys).
Book ChapterDOI
Selenocysteine Biosynthesis, Selenoproteins, and Selenoproteomes
TL;DR: Roles of selenium and selenoproteins in health have also been addressed through sophisticated transgenic/knockout models that targeted removal or modulation of Sec tRNA expression.
Journal ArticleDOI
Systematic age‐, organ‐, and diet‐associated ionome remodeling and the development of ionomic aging clocks
TL;DR: It was found that while the entire ionome steadily transitions along the young‐to‐old trajectory, individual organs are characterized by distinct element changes, and in general aging was characterized by the reduced levels of elements as well as their increased variance.