Valdir Cechinel Filho

TL;DR: Its antinociceptive effect was insensitive to naloxone, suggesting the lack of involvement of endogenous opioid, was not modulated by adrenal glands and does not involve interaction with the L-arginine-nitric oxide pathway, activation of alpha-1 adrenoceptors or tau-aminobutyric acidB receptors, but requires, at least in part, the serotoninergic pathway.

TL;DR: The mechanisms underlying the analgesic effects of the hydroalcoholic extracts of Phyllanthus urinaria and P. niruri against formalin-induced nociception in mice are examined and the action of both HEs against capsaicin-mediated pain is investigated.

TL;DR: Findings suggest that stigmasterol and beta-sitosterol may account, at least in part, for the antinociceptive actions reported previously for the hydroalcoholic extract of Phyllanthus corcovadensis.

TL;DR: The results showed that at a dose of 50 mg/kg, these compounds reduced the percentage of ulcer by around 71.26 ± 9.26%, which may be attributed, at least in part, to the antiulcerogenic activity of P. cyparissias.

TL;DR: The antifungal activity of P. solmsianum seems to be related mainly to the presence of compounds 2, 3 (neolignans) and 4 (flavonoid), however it was verified that another active compound, as yet unidentified, exists in the plant.