V
Vanessa L. Herring
Researcher at University of Tennessee Health Science Center
Publications - 18
Citations - 958
Vanessa L. Herring is an academic researcher from University of Tennessee Health Science Center. The author has contributed to research in topics: High-performance liquid chromatography & Mass spectrometry. The author has an hindex of 15, co-authored 18 publications receiving 853 citations.
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Journal ArticleDOI
The role of human carboxylesterases in drug metabolism: have we overlooked their importance?
TL;DR: Evidence exists that genetic polymorphisms, drug‐drug interactions, drug-disease interactions and other factors are important determinants of the variability in the therapeutic response to carboxylesterase‐substrate drugs.
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Intermittent and continuous ceftazidime infusion for critically ill trauma patients
Scott D. Hanes,G. Christopher Wood,Vanessa L. Herring,Martin A. Croce,Timothy C. Fabian,Elizabeth Pritchard,Bradley A. Boucher +6 more
TL;DR: Both intermittent and continuous ceftazidime regimens were equally effective for the treatment of nosocomial pneumonia caused by less virulent bacteria.
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Aerosolized Ceftazidime for Prevention of Ventilator-Associated Pneumonia and Drug Effects on the Proinflammatory Response in Critically Ill Trauma Patients
G. Christopher Wood,Bradley A. Boucher,Martin A. Croce,Scott D. Hanes,Vanessa L. Herring,Timothy C. Fabian +5 more
TL;DR: The safety and efficacy of aerosolized ceftazidime for prevention of ventilator‐associated pneumonia (VAP) and the effects of the drug on the proinflammatory response are evaluated.
Journal ArticleDOI
Identification of Carboxylesterase-Dependent Dabigatran Etexilate Hydrolysis
TL;DR: Results suggest that after oral administration of DabE to humans, DABE is hydrolyzed by intestinal CES2 to the intermediate M2 metabolite followed by hydrolysis of M2 to DAB in the liver by CES1, and carboxylesterase-mediated hydrolytic process was not inhibited by alcohol.
Journal Article
CYP1A2 and CYP2D6 4-Hydroxylate Propranolol and Both Reactions Exhibit Racial Differences
TL;DR: It is found that both CYP1A2 and CYP2D6 catalyze formation of 4-hydroxypropranolol and that both enzymes exhibited racial differences in this reaction, which may have relevance to drug efficacy, toxicity, or carcinogen activation for CYP 1A2 or CYP 2D6 substrates.